TNFα Signaling Exposes Latent Estrogen Receptor Binding Sites to Alter the Breast Cancer Cell Transcriptome

The interplay between mitogenic and proinflammatory signaling pathways plays key roles in determining the phenotypes and clinical outcomes of breast cancers. Using GRO-seq in MCF-7 cells, we defined the immediate transcriptional effects of crosstalk between estradiol (E2) and TNFα, identifying a lar...

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Veröffentlicht in:	Molecular cell 2015-04, Vol.58 (1), p.21-34
Hauptverfasser:	Franco, Hector L., Nagari, Anusha, Kraus, W. Lee
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cell Proliferation - drug effects Estradiol - pharmacology Estrogen Receptor alpha - antagonists & inhibitors Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Hepatocyte Nuclear Factor 3-alpha - genetics Hepatocyte Nuclear Factor 3-alpha - metabolism Humans MCF-7 Cells NF-kappa B - genetics NF-kappa B - metabolism Protein Binding - drug effects RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction Survival Analysis Transcriptome Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology
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