Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation

We used an inducible mouse model expressing the Tau repeat domain with the pro-aggregant mutation ΔK280 to analyze presynaptic Tau pathology in the hippocampus. Expression of pro-aggregant Tau(RDΔ) leads to phosphorylation, aggregation and missorting of Tau in area CA3. To test presynaptic pathophys...

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Veröffentlicht in:	Acta neuropathologica communications 2015-04, Vol.3 (1), p.23-23, Article 23
Hauptverfasser:	Decker, Jochen Martin, Krüger, Lars, Sydow, Astrid, Zhao, Shanting, Frotscher, Michael, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Calcium - physiology Calcium Signaling - physiology Cell Culture Techniques Disease Models, Animal Electrophysiology Genetic aspects Hippocampus - physiology Long-Term Potentiation - physiology Mice Mice, Knockout Mossy Fibers, Hippocampal - physiology Neuronal Plasticity - physiology Synaptic Transmission - physiology tau Proteins - deficiency tau Proteins - genetics tau Proteins - metabolism
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