β1 and β4 integrins: from breast development to clinical practice
Following a highly dynamic and complex dialogue between the epithelium and the surrounding microenvironment, the mammary gland develops into a branching structure during puberty, buds during pregnancy, forms intricate polar acini during lactation and, once the babies are weaned, remodels and involut...
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| Veröffentlicht in: | Breast cancer research : BCR 2014, Vol.16 (5), p.459-459, Article 459 |
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| creator | Nisticò, Paola Di Modugno, Francesca Spada, Sheila Bissell, Mina J |
| description | Following a highly dynamic and complex dialogue between the epithelium and the surrounding microenvironment, the mammary gland develops into a branching structure during puberty, buds during pregnancy, forms intricate polar acini during lactation and, once the babies are weaned, remodels and involutes. At every stage of menstrual and pregnancy cycles, interactions between the cells and the extracellular matrix (ECM) and homotypic and heterotypic cell–cell interactions give rise to the architecture and function of the gland at that junction. These orchestrated programs would not be possible without the important role of the ECM receptors, integrins being the prime examples. The ECM–integrin axis regulates many crucial cellular functions including survival, migration and quiescence; the imbalance in any of these processes could contribute to oncogenesis. In this review we spotlight the involvement of two prominent integrin subunits, β1 and β4 integrins, in cross-talk with tyrosine kinase receptors, and we discuss the roles of these integrin subunits in the biology of normal breast differentiation and as potential prognostic and therapeutic targets in breast cancer. |
| doi_str_mv | 10.1186/s13058-014-0459-x |
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Di Modugno, Francesca ; Spada, Sheila ; Bissell, Mina J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b608x-93640118dc18c437ab0ed27fcba5419f4cc060750c4c704ce1d39e702341a8913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>Animals</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Adhesion</topic><topic>Disease Progression</topic><topic>Drug Resistance, Neoplasm</topic><topic>Female</topic><topic>Humans</topic><topic>Integrin beta1 - physiology</topic><topic>Integrin beta4 - physiology</topic><topic>Mammary Glands, Human - growth & development</topic><topic>Mammary Glands, Human - metabolism</topic><topic>Oncology</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nisticò, Paola</creatorcontrib><creatorcontrib>Di Modugno, Francesca</creatorcontrib><creatorcontrib>Spada, Sheila</creatorcontrib><creatorcontrib>Bissell, Mina J</creatorcontrib><creatorcontrib>Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Breast cancer research : BCR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nisticò, Paola</au><au>Di Modugno, Francesca</au><au>Spada, Sheila</au><au>Bissell, Mina J</au><aucorp>Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>β1 and β4 integrins: from breast development to clinical practice</atitle><jtitle>Breast cancer research : BCR</jtitle><addtitle>Breast Cancer Res</addtitle><date>2014</date><risdate>2014</risdate><volume>16</volume><issue>5</issue><spage>459</spage><epage>459</epage><pages>459-459</pages><artnum>459</artnum><issn>1465-542X</issn><issn>1465-5411</issn><eissn>1465-542X</eissn><abstract>Following a highly dynamic and complex dialogue between the epithelium and the surrounding microenvironment, the mammary gland develops into a branching structure during puberty, buds during pregnancy, forms intricate polar acini during lactation and, once the babies are weaned, remodels and involutes. 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| subjects | 60 APPLIED LIFE SCIENCES Animals Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Adhesion Disease Progression Drug Resistance, Neoplasm Female Humans Integrin beta1 - physiology Integrin beta4 - physiology Mammary Glands, Human - growth & development Mammary Glands, Human - metabolism Oncology Review |
| title | β1 and β4 integrins: from breast development to clinical practice |
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