New tool for EDC research: in vivo assay screens for estrogenic effects
With more than 84,000 chemicals currently listed in the Toxic Substances Control Act inventory[1] and many of them lacking significant toxicologic data,[2] it's no easy task to pick out potential endocrine-disrupting compounds. [3] High-throughput in vitro assays used by programs such as the U....
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| Veröffentlicht in: | Environmental health perspectives 2015-04, Vol.123 (4), p.A95-A95 |
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| container_title | Environmental health perspectives |
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| creator | Arnold, Carrie |
| description | With more than 84,000 chemicals currently listed in the Toxic Substances Control Act inventory[1] and many of them lacking significant toxicologic data,[2] it's no easy task to pick out potential endocrine-disrupting compounds. [3] High-throughput in vitro assays used by programs such as the U.S. Environmental Protection Agency's ToxCast(TM) help with preliminary screening, but they can't identify how a compound may affect the body, says first author Sylvia Hewitt of the National Institute of Environmental Health Sciences. |
| doi_str_mv | 10.1289/ehp.123-A95 |
| format | Article |
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| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Alternative Test Models Animals Biomarkers Chemical Testing Chemicals Endocrine Disruptors Endocrine Disruptors - toxicity Environmental protection Estrogens Female Science Selections Studies Uterus Uterus - drug effects |
| title | New tool for EDC research: in vivo assay screens for estrogenic effects |
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