Effect of Excipients on Acetaminophen Metabolism and Its Implications for Prevention of Liver Injury

Acetaminophen poisoning is the most frequent cause of acute hepatic failure in the US. Toxicity requires reductive metabolism of acetaminophen, primarily via CYP2E1. Liquid acetaminophen preparations contain propylene glycol, a common excipient that has been shown to reduce hepatocellular injury in...

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Veröffentlicht in:	Journal of clinical pharmacology 2013-04, Vol.53 (4), p.413-420
Hauptverfasser:	Ganetsky, Michael, Böhlke, Mark, Pereira, Luis, Williams, David, LeDuc, Barbara, Guatam, Shiva, Salhanick, Steven D.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetaminophen Acetaminophen - analogs & derivatives Acetaminophen - metabolism Acetaminophen - pharmacokinetics Adult Analgesics Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Area Under Curve Chemical and Drug Induced Liver Injury - prevention & control Cross-Over Studies CYP2E1 Cytochrome P-450 CYP2E1 Inhibitors Dosage Forms Excipients - administration & dosage Female Humans Liver liver failure Male Metabolism Metabolites propylene glycol Propylene Glycol - administration & dosage Propylene Glycol - blood Sulfates - metabolism
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