Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H+ exchanger NHE3 dysfunction in human and murine colitis

A dysfunction of the Na + /H + exchanger isoform 3 (NHE3) significantly contributes to the reduced salt absorptive capacity of the inflamed intestine. We previously reported a strong decrease in the NHERF family member PDZK1 (NHERF3), which binds to NHE3 and regulates its function in a mouse model o...

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Veröffentlicht in:	Pflügers Archiv 2015-08, Vol.467 (8), p.1795-1807
Hauptverfasser:	Yeruva, Sunil, Chodisetti, Giriprakash, Luo, Min, Chen, Mingmin, Cinar, Ayhan, Ludolph, Lisa, Lünnemann, Maria, Goldstein, Julia, Singh, Anurag Kumar, Riederer, Brigitte, Bachmann, Oliver, Bleich, Andre, Gereke, Markus, Bruder, Dunja, Hagen, Susan, He, Peijian, Yun, Chris, Seidler, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Biopsy Caco-2 Cells Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology Colitis - chemically induced Colitis - genetics Colitis - metabolism Colitis - pathology Colon - metabolism Colon - pathology Dextran Sulfate Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation Enterocytes - metabolism Enterocytes - pathology Human Physiology Humans Ileitis - chemically induced Ileitis - genetics Ileitis - metabolism Ileitis - pathology Ileum - metabolism Ileum - pathology Inflammation Mediators - metabolism Interleukin-10 - genetics Interleukin-10 - metabolism Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mice, 129 Strain Mice, Knockout Microvilli - metabolism Molecular and Cellular Mechanisms of Disease Molecular Medicine Neurosciences Receptors Retrospective Studies RNA Interference RNA, Messenger - metabolism Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - metabolism Transfection Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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