Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer

TP53 is the most frequently altered gene in head and neck squamous cell carcinoma, with mutations occurring in over two-thirds of cases, but the prognostic significance of these mutations remains elusive. In the current study, we evaluated a novel computational approach termed evolutionary action (E...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-04, Vol.75 (7), p.1527-1536
Hauptverfasser:	Neskey, David M, Osman, Abdullah A, Ow, Thomas J, Katsonis, Panagiotis, McDonald, Thomas, Hicks, Stephanie C, Hsu, Teng-Kuei, Pickering, Curtis R, Ward, Alexandra, Patel, Ameeta, Yordy, John S, Skinner, Heath D, Giri, Uma, Sano, Daisuke, Story, Michael D, Beadle, Beth M, El-Naggar, Adel K, Kies, Merrill S, William, William N, Caulin, Carlos, Frederick, Mitchell, Kimmel, Marek, Myers, Jeffrey N, Lichtarge, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - secondary Cell Line, Tumor Gene Expression Regulation, Neoplastic Genetic Association Studies Genomics Head and Neck Neoplasms - genetics Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Humans Kaplan-Meier Estimate Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - secondary Mutation Neoplasm Invasiveness Proportional Hazards Models Transcriptome Tumor Suppressor Protein p53 - genetics
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