Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells

Abstract Objective Significant reductions in gynecologic (GYN) cancer mortality and morbidity require treatments that prevent and reverse resistance to chemotherapy and radiation. The objective of this study was to determine if pharmacologic inhibition of key DNA damage response kinases in GYN cance...

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Veröffentlicht in:	Gynecologic oncology 2015-03, Vol.136 (3), p.554-561
Hauptverfasser:	Teng, Pang-ning, Bateman, Nicholas W, Darcy, Kathleen M, Hamilton, Chad A, Maxwell, George Larry, Bakkenist, Christopher J, Conrads, Thomas P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors ATM ATR Biomarkers, Tumor - antagonists & inhibitors Cell Line, Tumor Cisplatin - pharmacology Cisplatin - therapeutic use Cisplatin resistance DNA Damage - drug effects DNA damage repair response DNA Repair - drug effects Drug Resistance, Neoplasm - drug effects Female Genital Neoplasms, Female - drug therapy Genital Neoplasms, Female - enzymology Genital Neoplasms, Female - radiotherapy Gynecologic cancer Hematology, Oncology and Palliative Medicine Humans Ionizing radiation Morpholines - pharmacology Obstetrics and Gynecology Oxazines - pharmacology Protein Kinase Inhibitors - pharmacology Pyrones - pharmacology Quinolines - pharmacology
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