Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

The mammary epithelium is thought to be stabilized by cell-cell adhesion mediated mainly by E-cadherin (E-cad). Here, we show that another cadherin, retinal cadherin (R-cad), is critical for maintenance of the epithelial phenotype. R-cad is expressed in nontransformed mammary epithelium but absent f...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-06, Vol.69 (12), p.5030-5038
Hauptverfasser:	AGIOSTRATIDOU, Georgia, MAOMI LI, EUGENIN, Eliseo, LOUDIG, Olivier, PHILLIPS, Greg R, LOCKER, Joseph, HAZAN, Rachel B, SUYAMA, Kimita, BADANO, Ines, KEREN, Rinat, CHUNG, Su, ANZOVINO, Amy, HULIT, James, BINZHI QIAN, BOUZAHZAH, Boumediene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Base Sequence Biological and medical sciences Cadherins - metabolism Cadherins - physiology Cell Line DNA Primers Female Humans Immunohistochemistry Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Medical sciences Mice Mice, Inbred BALB C Neoplasm Invasiveness Neoplasm Metastasis Pharmacology. Drug treatments Polymerase Chain Reaction Retina - metabolism RNA, Small Interfering Tumors
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