Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled

The cytoplasmic protein Dishevelled (Dvl) and the associated membrane-bound receptor Frizzled (Fz) are essential in canonical and noncanonical Wnt signaling pathways. However, the molecular mechanisms underlying this signaling are not well understood. By using NMR spectroscopy, we determined that an...

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Veröffentlicht in:	Molecular cell 2003-11, Vol.12 (5), p.1251-1260
Hauptverfasser:	Wong, Hing-C., Bourdelas, Audrey, Krauss, Anke, Lee, Ho-Jin, Shao, Youming, Wu, Dianqing, Mlodzik, Marek, Shi, De-Li, Zheng, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Binding Sites Body Patterning Carrier Proteins - genetics Carrier Proteins - metabolism Dishevelled Proteins Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Frizzled Receptors Homeodomain Proteins - metabolism Humans Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Microinjections Models, Molecular Molecular Sequence Data Morphogenesis - physiology Nuclear Proteins Peptide Fragments - genetics Peptide Fragments - metabolism Phosphoproteins - chemistry Phosphoproteins - genetics Phosphoproteins - metabolism Protein Binding Protein Structure, Tertiary Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptors, G-Protein-Coupled Sequence Alignment Signal Transduction - physiology Two-Hybrid System Techniques Wnt Proteins Xenopus laevis Xenopus Proteins - genetics Xenopus Proteins - metabolism Zebrafish Proteins
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