Exo-Selective Reductive Macrocyclization of Ynals

A general protocol for the highly exo-selective macrocyclization of ynals using a nickel/N-heterocyclic carbene catalyst system has been developed. A series of 10- to 21-membered macrocycles bearing an exomethylene substituent was synthesized in good yields with excellent regioselectivity (exo/endo...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic letters 2015-03, Vol.17 (6), p.1493-1496
Hauptverfasser:	Wang, Hengbin, Negretti, Solymar, Knauff, Allison R, Montgomery, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry carbenes Catalysis catalysts chemical reactions chemical structure Cyclization Macrocyclic Compounds - chemical synthesis Macrocyclic Compounds - chemistry Methane - analogs & derivatives Methane - chemistry Molecular Structure Nickel - chemistry regioselectivity Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!