Posttranslational Modifications in Microcin B17 Define an Additional Class of DNA Gyrase Inhibitor

Drugs that inhibit the activity of DNA gyrase fall almost exclusively into two structural classes, the quinolones and the coumarins. A third class of DNA gyrase inhibitor is defined by the ribosomally synthesized peptide antibiotic microcin B17 (MccB17). MccB17 contains 43 amino acid residues, but 1...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-05, Vol.91 (10), p.4519-4523
Hauptverfasser:	Yorgey, Peter, Lee, Jonathan, Kordel, Johann, Vivas, Eugenio, Warner, Philip, Jebaratnam, David, Kolter, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Antibiotics Bacteriocins - biosynthesis Bacteriocins - chemistry Bacteriocins - isolation & purification Biochemistry Cysteine - analysis Deoxyribonucleic acid DNA Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Magnetic Resonance Spectroscopy Mass Spectrometry Mass spectroscopy Molecular Sequence Data Music analysis Oxazoles Peptide Fragments - chemistry Peptide Fragments - isolation & purification Protein Conformation Protein Processing, Post-Translational Protons Quinolones Thiazoles Topoisomerase II Inhibitors
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