Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas
Ameloblastoma behavior is related to the potential of tumor cells to inhibit apoptosis and to initiate a proliferative phase. This study was performed to compare the immunoexpression of Survivin with Bcl-2, Bax, and Ki-67 and to associate them with the histopathological type of each variant of amelo...
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| creator | Salazar-Rodriguez, Sirced Damian-Matsumura, Pablo Molina-Frechero, Nelly González-González, Rogelio Bologna-Molina, Ronell |
| description | Ameloblastoma behavior is related to the potential of tumor cells to inhibit apoptosis and to initiate a proliferative phase. This study was performed to compare the immunoexpression of Survivin with Bcl-2, Bax, and Ki-67 and to associate them with the histopathological type of each variant of ameloblastoma. Material and Methods. Using the World Health Organization (WHO) criteria for ameloblastoma, 110 cases were selected. The cases were classified as solid/multicystic and unicystic ameloblastomas. Cellular counts of cytoplasmic immunoexpression were assessed for cytoplasmic Survivin, Bcl-2, and Bax, while the nuclear immunoexpression of Survivin and Ki-67 was assessed using label index. Results. Cytoplasmic Survivin and Bcl-2 showed higher percentages of immunoexpression in solid multicystic ameloblastomas compared to unicystic ameloblastomas (P |
| doi_str_mv | 10.1155/2015/301781 |
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This study was performed to compare the immunoexpression of Survivin with Bcl-2, Bax, and Ki-67 and to associate them with the histopathological type of each variant of ameloblastoma. Material and Methods. Using the World Health Organization (WHO) criteria for ameloblastoma, 110 cases were selected. The cases were classified as solid/multicystic and unicystic ameloblastomas. Cellular counts of cytoplasmic immunoexpression were assessed for cytoplasmic Survivin, Bcl-2, and Bax, while the nuclear immunoexpression of Survivin and Ki-67 was assessed using label index. Results. Cytoplasmic Survivin and Bcl-2 showed higher percentages of immunoexpression in solid multicystic ameloblastomas compared to unicystic ameloblastomas (P<0.05). Bax, Ki-67, and nuclear Survivin were expressed in higher percentages in unicystic ameloblastomas. Conclusions. Cytoplasmic Survivin and Bcl-2 immunoexpression levels were elevated in relation to Bax immunoexpression, suggesting aggressive ameloblastoma behavior, while Ki-67 and nuclear Survivin immunoexpression may be associated with the type of tumor morphology that influences cellular counts or with the greater capacity for cellular proliferation and tumor growth.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2015/301781</identifier><identifier>PMID: 25866434</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Ameloblastoma - metabolism ; Ameloblastoma - pathology ; Apoptosis ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Cell Proliferation ; Development and progression ; Gene expression ; Genetic aspects ; Health aspects ; Humans ; Inhibitor of Apoptosis Proteins - genetics ; Inhibitor of Apoptosis Proteins - metabolism ; Mouth cancer ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Properties ; Survivin</subject><ispartof>Disease markers, 2015-01, Vol.2015 (2015), p.1-7</ispartof><rights>Copyright © 2015 Rogelio González-González et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Rogelio González-González et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-83302510bd2d328bfb955aa31e79db8ea5cb7ca23f08f8d22750693565ab31c33</citedby><cites>FETCH-LOGICAL-c467t-83302510bd2d328bfb955aa31e79db8ea5cb7ca23f08f8d22750693565ab31c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381570/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381570/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25866434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Liotta, Lance A.</contributor><creatorcontrib>Salazar-Rodriguez, Sirced</creatorcontrib><creatorcontrib>Damian-Matsumura, Pablo</creatorcontrib><creatorcontrib>Molina-Frechero, Nelly</creatorcontrib><creatorcontrib>González-González, Rogelio</creatorcontrib><creatorcontrib>Bologna-Molina, Ronell</creatorcontrib><title>Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Ameloblastoma behavior is related to the potential of tumor cells to inhibit apoptosis and to initiate a proliferative phase. This study was performed to compare the immunoexpression of Survivin with Bcl-2, Bax, and Ki-67 and to associate them with the histopathological type of each variant of ameloblastoma. Material and Methods. Using the World Health Organization (WHO) criteria for ameloblastoma, 110 cases were selected. The cases were classified as solid/multicystic and unicystic ameloblastomas. Cellular counts of cytoplasmic immunoexpression were assessed for cytoplasmic Survivin, Bcl-2, and Bax, while the nuclear immunoexpression of Survivin and Ki-67 was assessed using label index. Results. Cytoplasmic Survivin and Bcl-2 showed higher percentages of immunoexpression in solid multicystic ameloblastomas compared to unicystic ameloblastomas (P<0.05). Bax, Ki-67, and nuclear Survivin were expressed in higher percentages in unicystic ameloblastomas. Conclusions. Cytoplasmic Survivin and Bcl-2 immunoexpression levels were elevated in relation to Bax immunoexpression, suggesting aggressive ameloblastoma behavior, while Ki-67 and nuclear Survivin immunoexpression may be associated with the type of tumor morphology that influences cellular counts or with the greater capacity for cellular proliferation and tumor growth.</description><subject>Ameloblastoma - metabolism</subject><subject>Ameloblastoma - pathology</subject><subject>Apoptosis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cell Proliferation</subject><subject>Development and progression</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Inhibitor of Apoptosis Proteins - genetics</subject><subject>Inhibitor of Apoptosis Proteins - metabolism</subject><subject>Mouth cancer</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Properties</subject><subject>Survivin</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqN0c2P1CAYBnBiNO64evJuSLwYTd0XKIVeTCaTVSfZROPHmVBKtxhaKrQz-t_LbNfNevPE4f3x8JIHoecE3hLC-QUFwi8YECHJA7QhUvBCVgweog1QIQugJZyhJyn9ACC0LuvH6IxyWVUlKzfouB-GZQy9S3MwvR2c0R5f_pqiTcmFEYcOf13iwR3ciPXY4v2c8Bfr9ZyHqXcTPrq5xzvrPd5OYZpDcukGfo7Bu87GG4nz7e1gfWi8zg8NOj1Fjzrtk312e56j7-8vv-0-FlefPux326vClJWYC8kYUE6gaWnLqGy6puZca0asqNtGWs1NI4ymrAPZyZZSwaGqGa-4bhgxjJ2jd2vutDSDbY0d56i9mqIbdPytgnbq38noenUdDqpkknABOeDVbUAMPxebZjW4ZPJ_9WjDkhSpBAMhJK0yfbnSa-2tcmMXcqI5cbUteSkkE4xm9WZVJoaUou3uliGgToWqU6FqLTTrF_f3v7N_G8zg9Qp6N7b66P4vzWZiO30PV1ADsD-Wm7PL</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Salazar-Rodriguez, Sirced</creator><creator>Damian-Matsumura, Pablo</creator><creator>Molina-Frechero, Nelly</creator><creator>González-González, Rogelio</creator><creator>Bologna-Molina, Ronell</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas</title><author>Salazar-Rodriguez, Sirced ; Damian-Matsumura, Pablo ; Molina-Frechero, Nelly ; González-González, Rogelio ; Bologna-Molina, Ronell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-83302510bd2d328bfb955aa31e79db8ea5cb7ca23f08f8d22750693565ab31c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Ameloblastoma - metabolism</topic><topic>Ameloblastoma - pathology</topic><topic>Apoptosis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cell Proliferation</topic><topic>Development and progression</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Inhibitor of Apoptosis Proteins - genetics</topic><topic>Inhibitor of Apoptosis Proteins - metabolism</topic><topic>Mouth cancer</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Properties</topic><topic>Survivin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salazar-Rodriguez, Sirced</creatorcontrib><creatorcontrib>Damian-Matsumura, Pablo</creatorcontrib><creatorcontrib>Molina-Frechero, Nelly</creatorcontrib><creatorcontrib>González-González, Rogelio</creatorcontrib><creatorcontrib>Bologna-Molina, Ronell</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salazar-Rodriguez, Sirced</au><au>Damian-Matsumura, Pablo</au><au>Molina-Frechero, Nelly</au><au>González-González, Rogelio</au><au>Bologna-Molina, Ronell</au><au>Liotta, Lance A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>2015</volume><issue>2015</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Ameloblastoma behavior is related to the potential of tumor cells to inhibit apoptosis and to initiate a proliferative phase. This study was performed to compare the immunoexpression of Survivin with Bcl-2, Bax, and Ki-67 and to associate them with the histopathological type of each variant of ameloblastoma. Material and Methods. Using the World Health Organization (WHO) criteria for ameloblastoma, 110 cases were selected. The cases were classified as solid/multicystic and unicystic ameloblastomas. Cellular counts of cytoplasmic immunoexpression were assessed for cytoplasmic Survivin, Bcl-2, and Bax, while the nuclear immunoexpression of Survivin and Ki-67 was assessed using label index. Results. Cytoplasmic Survivin and Bcl-2 showed higher percentages of immunoexpression in solid multicystic ameloblastomas compared to unicystic ameloblastomas (P<0.05). Bax, Ki-67, and nuclear Survivin were expressed in higher percentages in unicystic ameloblastomas. Conclusions. Cytoplasmic Survivin and Bcl-2 immunoexpression levels were elevated in relation to Bax immunoexpression, suggesting aggressive ameloblastoma behavior, while Ki-67 and nuclear Survivin immunoexpression may be associated with the type of tumor morphology that influences cellular counts or with the greater capacity for cellular proliferation and tumor growth.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25866434</pmid><doi>10.1155/2015/301781</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ameloblastoma - metabolism Ameloblastoma - pathology Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Proliferation Development and progression Gene expression Genetic aspects Health aspects Humans Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Mouth cancer Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Properties Survivin |
| title | Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas |
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