Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism

High-fat diet-induced obesity (DIO) is a major contributor to type II diabetes and micro- and macro-vascular complications leading to peripheral vascular disease (PVD). Metabolic abnormalities of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) from obese individuals could potentia...

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Veröffentlicht in:	European heart journal 2015-04, Vol.36 (13), p.806-816
Hauptverfasser:	Gu, Mingxia, Mordwinkin, Nicholas M, Kooreman, Nigel G, Lee, Jaecheol, Wu, Haodi, Hu, Shijun, Churko, Jared M, Diecke, Sebastian, Burridge, Paul W, He, Chunjiang, Barron, Frances E, Ong, Sang-Ging, Gold, Joseph D, Wu, Joseph C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Apoptosis - physiology Basic Science Cell Differentiation Diet, High-Fat Endothelial Cells - physiology Enzyme Inhibitors - pharmacology Fibroblasts - physiology Hindlimb - blood supply Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Induced Pluripotent Stem Cells - physiology Injections, Intramuscular Ischemia - physiopathology Ischemia - prevention & control Mice, Inbred C57BL Muscle, Skeletal Muscular Diseases - prevention & control NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - physiology Nitric Oxide Synthase Type III - metabolism Obesity - physiopathology Oxidative Stress - physiology Pravastatin - pharmacology Proto-Oncogene Proteins c-akt - metabolism Random Allocation Reperfusion Injury - physiopathology Signal Transduction
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