The beneficial effects of exercise on cartilage are lost in mice with reduced levels of ECSOD in tissues

Osteoarthritis (OA) is associated with increased mechanical damage to joint cartilage. We have previously found that extracellular superoxide dismutase (ECSOD) is decreased in OA joint fluid and cartilage, suggesting oxidant damage may play a role in OA. We explored the effect of forced running as a...

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Veröffentlicht in:	Journal of applied physiology (1985) 2015-03, Vol.118 (6), p.760-767
Hauptverfasser:	Pate, Kathryn M, Sherk, Vanessa D, Carpenter, R Dana, Weaver, Michael, Crapo, Silvia, Gally, Fabienne, Chatham, Lillian S, Goldstrohm, David A, Crapo, James D, Kohrt, Wendy M, Bowler, Russell P, Oberley-Deegan, Rebecca E, Regan, Elizabeth A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Bone and Bones - metabolism Bone and Bones - physiology Cartilage Cartilage, Articular - metabolism Cartilage, Articular - physiology Exercise Histology Knee Joint - metabolism Knee Joint - physiology Male Mice Mice, Transgenic - genetics Mice, Transgenic - metabolism Mice, Transgenic - physiology Osteoarthritis - genetics Osteoarthritis - metabolism Osteoarthritis - physiopathology Physical Conditioning, Animal - physiology Physiology Polymorphism Polymorphism, Genetic - genetics Rodents Running - physiology Superoxide Dismutase - genetics Superoxide Dismutase - metabolism
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