Radiation-induced glioblastoma signaling cascade regulates viability, apoptosis and differentiation of neural stem cells (NSC)

Ionizing radiation alone or in combination with chemotherapy is the main treatment modality for brain tumors including glioblastoma. Adult neurons and astrocytes demonstrate substantial radioresistance; in contrast, human neural stem cells (NSC) are highly sensitive to radiation via induction of apo...

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Veröffentlicht in:	Apoptosis (London) 2014-12, Vol.19 (12), p.1736-1754
Hauptverfasser:	Ivanov, Vladimir N., Hei, Tom K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - radiation effects Biochemistry Biomedical and Life Sciences Biomedicine Brain tumors Cancer Research Cell Biology Cell Communication - radiation effects Cell Differentiation - radiation effects Cell Survival - radiation effects Cytokines - metabolism Embryonic Stem Cells - metabolism Embryonic Stem Cells - pathology Embryonic Stem Cells - radiation effects Fas Ligand Protein - metabolism Gamma Rays Glioblastoma - metabolism Glioblastoma - pathology Humans Ionizing radiation Irradiation Ligands Neural Stem Cells - metabolism Neural Stem Cells - pathology Neural Stem Cells - radiation effects Oncology Original Paper Receptors, Death Domain - metabolism Signal Transduction - radiation effects Stem cells TNF-Related Apoptosis-Inducing Ligand - metabolism Virology
Online-Zugang:	Volltext
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