Clostridium difficile-associated diarrhea in adults
Clostridium difficile is the most important cause of nosocomial diarrhea in adults. Illness may range from mild watery diarrhea to life-threatening colitis. An antecedent disruption of the normal colonic flora followed by exposure to a toxigenic strain of C. difficile are necessary first steps in th...
Gespeichert in:
| Veröffentlicht in: | Canadian Medical Association journal (CMAJ) 2004-07, Vol.171 (1), p.51-58 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 58 |
|---|---|
| container_issue | 1 |
| container_start_page | 51 |
| container_title | Canadian Medical Association journal (CMAJ) |
| container_volume | 171 |
| creator | Poutanen, Susan M Simor, Andrew E |
| description | Clostridium difficile is the most important cause of nosocomial diarrhea in adults. Illness may range from mild watery diarrhea to life-threatening colitis. An antecedent disruption of the normal colonic flora followed by exposure to a toxigenic strain of C. difficile are necessary first steps in the pathogenesis of disease. Diagnosis is based primarily on the detection of C. difficile toxin A or toxin B. First-line treatment is with oral metronidazole therapy. Treatment with oral vancomycin therapy should be reserved for patients who have contraindications or intolerance to metronidazole or who fail to respond to first-line therapy. |
| doi_str_mv | 10.1503/cmaj.1031189 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_437686</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>670771581</sourcerecordid><originalsourceid>FETCH-LOGICAL-p189t-c8b6960077f4001515e6eea88d4e8376c1e13fcfc11b27533d302c21ca0bfecc3</originalsourceid><addsrcrecordid>eNpVkMtLxDAQxoMobl29eZbFe9dMJm2TgwdZfMGCFz2HNA83Sx9r0gr-9xZdRecyMDPf7_sYQs6BLqGgeGVavV0CRQAhD0gGXIicIZOHJKOC0RwlL2fkJKUtnQpZdUxmUDAUXIqM4Krp0xCDDWO7sMH7YELjcp1Sb4IenJ2GOsaN04vQLbQdmyGdkiOvm-TO9n1OXu5un1cP-frp_nF1s853U5QhN6IuZUlpVXlOKRRQuNI5LYTlTmBVGnCA3ngDULOqQLRImWFgNK29Mwbn5Pqbuxvr1lnjuiHqRu1iaHX8UL0O6v-mCxv12r8rPtFFOekv9_rYv40uDWrbj7GbIitGuZSV_Dq6-GvyS_95EX4CdfRpNw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204997986</pqid></control><display><type>article</type><title>Clostridium difficile-associated diarrhea in adults</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Poutanen, Susan M ; Simor, Andrew E</creator><creatorcontrib>Poutanen, Susan M ; Simor, Andrew E</creatorcontrib><description>Clostridium difficile is the most important cause of nosocomial diarrhea in adults. Illness may range from mild watery diarrhea to life-threatening colitis. An antecedent disruption of the normal colonic flora followed by exposure to a toxigenic strain of C. difficile are necessary first steps in the pathogenesis of disease. Diagnosis is based primarily on the detection of C. difficile toxin A or toxin B. First-line treatment is with oral metronidazole therapy. Treatment with oral vancomycin therapy should be reserved for patients who have contraindications or intolerance to metronidazole or who fail to respond to first-line therapy.</description><identifier>ISSN: 0820-3946</identifier><identifier>EISSN: 1488-2329</identifier><identifier>DOI: 10.1503/cmaj.1031189</identifier><identifier>PMID: 15238498</identifier><identifier>CODEN: CMAJAX</identifier><language>eng</language><publisher>Canada: CMA Impact, Inc</publisher><subject>Anti-Infective Agents - therapeutic use ; Bacterial Typing Techniques ; Canada - epidemiology ; Carrier State - microbiology ; Clostridium difficile - isolation & purification ; Clostridium difficile - pathogenicity ; Clostridium Infections - diagnosis ; Clostridium Infections - drug therapy ; Clostridium Infections - epidemiology ; Clostridium Infections - physiopathology ; Control ; Cross Infection - diagnosis ; Cross Infection - drug therapy ; Cross Infection - microbiology ; Cross Infection - physiopathology ; Diarrhea ; Diarrhea - diagnosis ; Diarrhea - drug therapy ; Diarrhea - microbiology ; Diarrhea - physiopathology ; Hospitals ; Humans ; Infections ; Infectious diseases ; Metronidazole - therapeutic use ; Recurrence ; Review ; Risk Factors ; Treatment</subject><ispartof>Canadian Medical Association journal (CMAJ), 2004-07, Vol.171 (1), p.51-58</ispartof><rights>Copyright Canadian Medical Association Jul 6, 2004</rights><rights>2004 Canadian Medical Association or its licensors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC437686/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC437686/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15238498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poutanen, Susan M</creatorcontrib><creatorcontrib>Simor, Andrew E</creatorcontrib><title>Clostridium difficile-associated diarrhea in adults</title><title>Canadian Medical Association journal (CMAJ)</title><addtitle>CMAJ</addtitle><description>Clostridium difficile is the most important cause of nosocomial diarrhea in adults. Illness may range from mild watery diarrhea to life-threatening colitis. An antecedent disruption of the normal colonic flora followed by exposure to a toxigenic strain of C. difficile are necessary first steps in the pathogenesis of disease. Diagnosis is based primarily on the detection of C. difficile toxin A or toxin B. First-line treatment is with oral metronidazole therapy. Treatment with oral vancomycin therapy should be reserved for patients who have contraindications or intolerance to metronidazole or who fail to respond to first-line therapy.</description><subject>Anti-Infective Agents - therapeutic use</subject><subject>Bacterial Typing Techniques</subject><subject>Canada - epidemiology</subject><subject>Carrier State - microbiology</subject><subject>Clostridium difficile - isolation & purification</subject><subject>Clostridium difficile - pathogenicity</subject><subject>Clostridium Infections - diagnosis</subject><subject>Clostridium Infections - drug therapy</subject><subject>Clostridium Infections - epidemiology</subject><subject>Clostridium Infections - physiopathology</subject><subject>Control</subject><subject>Cross Infection - diagnosis</subject><subject>Cross Infection - drug therapy</subject><subject>Cross Infection - microbiology</subject><subject>Cross Infection - physiopathology</subject><subject>Diarrhea</subject><subject>Diarrhea - diagnosis</subject><subject>Diarrhea - drug therapy</subject><subject>Diarrhea - microbiology</subject><subject>Diarrhea - physiopathology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Metronidazole - therapeutic use</subject><subject>Recurrence</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Treatment</subject><issn>0820-3946</issn><issn>1488-2329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVkMtLxDAQxoMobl29eZbFe9dMJm2TgwdZfMGCFz2HNA83Sx9r0gr-9xZdRecyMDPf7_sYQs6BLqGgeGVavV0CRQAhD0gGXIicIZOHJKOC0RwlL2fkJKUtnQpZdUxmUDAUXIqM4Krp0xCDDWO7sMH7YELjcp1Sb4IenJ2GOsaN04vQLbQdmyGdkiOvm-TO9n1OXu5un1cP-frp_nF1s853U5QhN6IuZUlpVXlOKRRQuNI5LYTlTmBVGnCA3ngDULOqQLRImWFgNK29Mwbn5Pqbuxvr1lnjuiHqRu1iaHX8UL0O6v-mCxv12r8rPtFFOekv9_rYv40uDWrbj7GbIitGuZSV_Dq6-GvyS_95EX4CdfRpNw</recordid><startdate>20040706</startdate><enddate>20040706</enddate><creator>Poutanen, Susan M</creator><creator>Simor, Andrew E</creator><general>CMA Impact, Inc</general><general>Canadian Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M3G</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20040706</creationdate><title>Clostridium difficile-associated diarrhea in adults</title><author>Poutanen, Susan M ; Simor, Andrew E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p189t-c8b6960077f4001515e6eea88d4e8376c1e13fcfc11b27533d302c21ca0bfecc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anti-Infective Agents - therapeutic use</topic><topic>Bacterial Typing Techniques</topic><topic>Canada - epidemiology</topic><topic>Carrier State - microbiology</topic><topic>Clostridium difficile - isolation & purification</topic><topic>Clostridium difficile - pathogenicity</topic><topic>Clostridium Infections - diagnosis</topic><topic>Clostridium Infections - drug therapy</topic><topic>Clostridium Infections - epidemiology</topic><topic>Clostridium Infections - physiopathology</topic><topic>Control</topic><topic>Cross Infection - diagnosis</topic><topic>Cross Infection - drug therapy</topic><topic>Cross Infection - microbiology</topic><topic>Cross Infection - physiopathology</topic><topic>Diarrhea</topic><topic>Diarrhea - diagnosis</topic><topic>Diarrhea - drug therapy</topic><topic>Diarrhea - microbiology</topic><topic>Diarrhea - physiopathology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Metronidazole - therapeutic use</topic><topic>Recurrence</topic><topic>Review</topic><topic>Risk Factors</topic><topic>Treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poutanen, Susan M</creatorcontrib><creatorcontrib>Simor, Andrew E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>CBCA Reference & Current Events</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian Medical Association journal (CMAJ)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poutanen, Susan M</au><au>Simor, Andrew E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clostridium difficile-associated diarrhea in adults</atitle><jtitle>Canadian Medical Association journal (CMAJ)</jtitle><addtitle>CMAJ</addtitle><date>2004-07-06</date><risdate>2004</risdate><volume>171</volume><issue>1</issue><spage>51</spage><epage>58</epage><pages>51-58</pages><issn>0820-3946</issn><eissn>1488-2329</eissn><coden>CMAJAX</coden><abstract>Clostridium difficile is the most important cause of nosocomial diarrhea in adults. Illness may range from mild watery diarrhea to life-threatening colitis. An antecedent disruption of the normal colonic flora followed by exposure to a toxigenic strain of C. difficile are necessary first steps in the pathogenesis of disease. Diagnosis is based primarily on the detection of C. difficile toxin A or toxin B. First-line treatment is with oral metronidazole therapy. Treatment with oral vancomycin therapy should be reserved for patients who have contraindications or intolerance to metronidazole or who fail to respond to first-line therapy.</abstract><cop>Canada</cop><pub>CMA Impact, Inc</pub><pmid>15238498</pmid><doi>10.1503/cmaj.1031189</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0820-3946 |
| ispartof | Canadian Medical Association journal (CMAJ), 2004-07, Vol.171 (1), p.51-58 |
| issn | 0820-3946 1488-2329 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_437686 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anti-Infective Agents - therapeutic use Bacterial Typing Techniques Canada - epidemiology Carrier State - microbiology Clostridium difficile - isolation & purification Clostridium difficile - pathogenicity Clostridium Infections - diagnosis Clostridium Infections - drug therapy Clostridium Infections - epidemiology Clostridium Infections - physiopathology Control Cross Infection - diagnosis Cross Infection - drug therapy Cross Infection - microbiology Cross Infection - physiopathology Diarrhea Diarrhea - diagnosis Diarrhea - drug therapy Diarrhea - microbiology Diarrhea - physiopathology Hospitals Humans Infections Infectious diseases Metronidazole - therapeutic use Recurrence Review Risk Factors Treatment |
| title | Clostridium difficile-associated diarrhea in adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T18%3A46%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clostridium%20difficile-associated%20diarrhea%20in%20adults&rft.jtitle=Canadian%20Medical%20Association%20journal%20(CMAJ)&rft.au=Poutanen,%20Susan%20M&rft.date=2004-07-06&rft.volume=171&rft.issue=1&rft.spage=51&rft.epage=58&rft.pages=51-58&rft.issn=0820-3946&rft.eissn=1488-2329&rft.coden=CMAJAX&rft_id=info:doi/10.1503/cmaj.1031189&rft_dat=%3Cproquest_pubme%3E670771581%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204997986&rft_id=info:pmid/15238498&rfr_iscdi=true |