LKB1/Mo25/STRAD Uniquely Impacts Sarcomeric Contractile Function and Posttranslational Modification

The myocardium undergoes extensive metabolic and energetic remodeling during the progression of cardiac disease. Central to remodeling are changes in the adenine nucleotide pool. Fluctuations in these pools can activate AMP-activated protein kinase (AMPK), the central regulator of cellular energetic...

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Veröffentlicht in:	Biophysical journal 2015-03, Vol.108 (6), p.1484-1494
Hauptverfasser:	Behunin, Samantha M., Lopez-Pier, Marissa A., Birch, Camille L., McKee, Laurel A.K., Danilo, Christiane, Khalpey, Zain, Konhilas, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism AMP-Activated Protein Kinases - metabolism Animals Binding sites Bioenergetics Biophysics Calcium - metabolism Cardiomyocytes Heart - physiology Kinases Male Molecular Machines, Motors, and Nanoscale Biophysics Muscle Contraction - physiology Phosphorylation Protein expression Protein Processing, Post-Translational Protein-Serine-Threonine Kinases - metabolism Rats, Sprague-Dawley Sarcomeres - physiology
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