P2X receptors trigger intracellular alkalization in isolated perfused mouse medullary thick ascending limb

Aims Extracellular ATP is an important regulator of renal tubular transport. Recently, we found that basolateral ATP markedly inhibits Na+ and Cl− absorption in mouse medullary thick ascending limb (mTAL) via a P2X receptor. The underlying mechanism that mediates this ATP‐dependent transport inhibit...

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Veröffentlicht in:	Acta Physiologica 2015-01, Vol.213 (1), p.277-284
Hauptverfasser:	de Bruijn, P. I. A., Bleich, M., Praetorius, H. A., Leipziger, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Separation - methods Hydrogen-Ion Concentration intracellular pH Intracellular Space - metabolism Ion Transport - physiology Kidney Medulla - metabolism loop of Henle Loop of Henle - metabolism Mice Na+/H+ exchanger 3 P2 receptors Potassium - metabolism purinergic Receptors, Purinergic P2X - metabolism Sodium - metabolism Sodium-Hydrogen Exchangers - metabolism Special Series on Renal Purinergic Signalling in Health and Disease
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