Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model

CD2-associated protein (CD2AP) is an SH3-containing scaffold adaptor protein which regulates the actin cytoskeleton. Recently, CD2AP was identified as a genetic risk factor for Alzheimer's disease (AD) by several genome-wide association studies. One of the hallmarks of AD is the accumulation of...

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Veröffentlicht in:	Molecular neurodegeneration 2015-03, Vol.10 (1), p.12-12, Article 12
Hauptverfasser:	Liao, Fan, Jiang, Hong, Srivatsan, Subhashini, Xiao, Qingli, Lefton, Katheryn B, Yamada, Kaoru, Mahan, Thomas E, Lee, Jin-Moo, Shaw, Andrey S, Holtzman, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - metabolism Alzheimer Disease - genetics Alzheimer Disease - metabolism Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - metabolism Animals Brain - metabolism Cytoskeletal Proteins - deficiency Cytoskeletal Proteins - metabolism Disease Models, Animal Genome-Wide Association Study Humans Mice, Transgenic Neuroblastoma - genetics Neuroblastoma - metabolism
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