A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning
Insect gustatory and odorant receptors (GRs and ORs) form a superfamily of novel transmembrane proteins, which are expressed in chemosensory neurons that detect environmental stimuli. Here we identify homologues of GR s ( Gustatory receptor-like ( Grl ) genes) in genomes across Protostomia, Deuteros...
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| Veröffentlicht in: | Nature communications 2015-02, Vol.6 (1), p.6243-6243, Article 6243 |
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| creator | Saina, Michael Busengdal, Henriette Sinigaglia, Chiara Petrone, Libero Oliveri, Paola Rentzsch, Fabian Benton, Richard |
| description | Insect gustatory and odorant receptors (GRs and ORs) form a superfamily of novel transmembrane proteins, which are expressed in chemosensory neurons that detect environmental stimuli. Here we identify homologues of
GR
s (
Gustatory receptor-like
(
Grl
) genes) in genomes across Protostomia, Deuterostomia and non-Bilateria. Surprisingly, two
Grls
in the cnidarian
Nematostella vectensis
,
NvecGrl1
and
NvecGrl2
, are expressed early in development, in the blastula and gastrula, but not at later stages when a putative chemosensory organ forms.
NvecGrl1
transcripts are detected around the aboral pole, considered the equivalent to the head-forming region of Bilateria. Morpholino-mediated knockdown of
NvecGrl1
causes developmental patterning defects of this region, leading to animals lacking the apical sensory organ. A deuterostome
Grl
from the sea urchin
Strongylocentrotus purpuratus
displays similar patterns of developmental expression. These results reveal an early evolutionary origin of the insect chemosensory receptor family and raise the possibility that their ancestral role was in embryonic development.
Insect gustatory and olfactory receptor genes encode transmembrane proteins that detect diverse chemicals, but their evolutionary origins are unclear. This study identifies homologues of these genes in non-Bilateria and reveals an unexpected role for one in sea anemone embryonic development. |
| doi_str_mv | 10.1038/ncomms7243 |
| format | Article |
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GR
s (
Gustatory receptor-like
(
Grl
) genes) in genomes across Protostomia, Deuterostomia and non-Bilateria. Surprisingly, two
Grls
in the cnidarian
Nematostella vectensis
,
NvecGrl1
and
NvecGrl2
, are expressed early in development, in the blastula and gastrula, but not at later stages when a putative chemosensory organ forms.
NvecGrl1
transcripts are detected around the aboral pole, considered the equivalent to the head-forming region of Bilateria. Morpholino-mediated knockdown of
NvecGrl1
causes developmental patterning defects of this region, leading to animals lacking the apical sensory organ. A deuterostome
Grl
from the sea urchin
Strongylocentrotus purpuratus
displays similar patterns of developmental expression. These results reveal an early evolutionary origin of the insect chemosensory receptor family and raise the possibility that their ancestral role was in embryonic development.
Insect gustatory and olfactory receptor genes encode transmembrane proteins that detect diverse chemicals, but their evolutionary origins are unclear. This study identifies homologues of these genes in non-Bilateria and reveals an unexpected role for one in sea anemone embryonic development.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms7243</identifier><identifier>PMID: 25692633</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 13/95 ; 14/34 ; 38 ; 38/23 ; 38/39 ; 38/77 ; 631/136/1455 ; 631/1647/2217/748 ; 631/181 ; 631/378/2626 ; 96 ; Animals ; Blastula - metabolism ; Body Patterning ; Chemoreceptor Cells - metabolism ; Cloning, Molecular ; Evolution, Molecular ; Gastrula - metabolism ; Gene Expression Regulation, Developmental ; Genome ; Genomics ; Humanities and Social Sciences ; Insect Proteins - metabolism ; Insecta ; multidisciplinary ; Neurons - metabolism ; Phylogeny ; Receptors, Cell Surface - metabolism ; Science ; Science (multidisciplinary) ; Sea Anemones - embryology ; Sea Anemones - genetics ; Sensory Receptor Cells - metabolism ; Signal Transduction ; Strongylocentrotus purpuratus - embryology ; Strongylocentrotus purpuratus - genetics</subject><ispartof>Nature communications, 2015-02, Vol.6 (1), p.6243-6243, Article 6243</ispartof><rights>Springer Nature Limited 2015</rights><rights>Copyright Nature Publishing Group Feb 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-b3529b100e1069b0c0e52013c9e7fc261b81c168324d278e5347c5c0f027ecd53</citedby><cites>FETCH-LOGICAL-c508t-b3529b100e1069b0c0e52013c9e7fc261b81c168324d278e5347c5c0f027ecd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374167/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374167/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,41103,42172,51559,53774,53776</link.rule.ids><linktorsrc>$$Uhttps://doi.org/10.1038/ncomms7243$$EView_record_in_Springer_Nature$$FView_record_in_$$GSpringer_Nature</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25692633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saina, Michael</creatorcontrib><creatorcontrib>Busengdal, Henriette</creatorcontrib><creatorcontrib>Sinigaglia, Chiara</creatorcontrib><creatorcontrib>Petrone, Libero</creatorcontrib><creatorcontrib>Oliveri, Paola</creatorcontrib><creatorcontrib>Rentzsch, Fabian</creatorcontrib><creatorcontrib>Benton, Richard</creatorcontrib><title>A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Insect gustatory and odorant receptors (GRs and ORs) form a superfamily of novel transmembrane proteins, which are expressed in chemosensory neurons that detect environmental stimuli. Here we identify homologues of
GR
s (
Gustatory receptor-like
(
Grl
) genes) in genomes across Protostomia, Deuterostomia and non-Bilateria. Surprisingly, two
Grls
in the cnidarian
Nematostella vectensis
,
NvecGrl1
and
NvecGrl2
, are expressed early in development, in the blastula and gastrula, but not at later stages when a putative chemosensory organ forms.
NvecGrl1
transcripts are detected around the aboral pole, considered the equivalent to the head-forming region of Bilateria. Morpholino-mediated knockdown of
NvecGrl1
causes developmental patterning defects of this region, leading to animals lacking the apical sensory organ. A deuterostome
Grl
from the sea urchin
Strongylocentrotus purpuratus
displays similar patterns of developmental expression. These results reveal an early evolutionary origin of the insect chemosensory receptor family and raise the possibility that their ancestral role was in embryonic development.
Insect gustatory and olfactory receptor genes encode transmembrane proteins that detect diverse chemicals, but their evolutionary origins are unclear. This study identifies homologues of these genes in non-Bilateria and reveals an unexpected role for one in sea anemone embryonic development.</description><subject>13/51</subject><subject>13/95</subject><subject>14/34</subject><subject>38</subject><subject>38/23</subject><subject>38/39</subject><subject>38/77</subject><subject>631/136/1455</subject><subject>631/1647/2217/748</subject><subject>631/181</subject><subject>631/378/2626</subject><subject>96</subject><subject>Animals</subject><subject>Blastula - metabolism</subject><subject>Body Patterning</subject><subject>Chemoreceptor Cells - metabolism</subject><subject>Cloning, Molecular</subject><subject>Evolution, Molecular</subject><subject>Gastrula - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genome</subject><subject>Genomics</subject><subject>Humanities and Social Sciences</subject><subject>Insect Proteins - metabolism</subject><subject>Insecta</subject><subject>multidisciplinary</subject><subject>Neurons - metabolism</subject><subject>Phylogeny</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sea Anemones - embryology</subject><subject>Sea Anemones - genetics</subject><subject>Sensory Receptor Cells - metabolism</subject><subject>Signal Transduction</subject><subject>Strongylocentrotus purpuratus - embryology</subject><subject>Strongylocentrotus purpuratus - genetics</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkV1LHTEQhoO0qKg3_QES8KZYjs3nZvemINIPQehNvU6z2dk1spusSfbA-fdGjtpjnZuZMA_vvOFF6BMlF5Tw-qu3YZqSYoLvoUNGBF1RxfiHnfkAnaR0T0rxhtZC7KMDJquGVZwfor-X2HrXmeiMx3dhCmMYFsChx-XtfAKb8bCkbHKIGxzBwlwm3C_eZhd8KgzuYA1jmCfw2Yy4Dd0GzyZniN754Rh97M2Y4OS5H6HbH9__XP1a3fz-eX11ebOyktR51XLJmpYSApRUTUssAckI5bYB1VtW0bamllY1Z6JjqgbJhbLSkp4wBbaT_Ah92-rOSztBZ4uZaEY9RzeZuNHBOP12492dHsJaC64ErVQR-PwsEMPDAinrySUL42g8hCVpWklVrouGFvTsP_Q-LNGX7z1RUrG6YqxQ51vKxpBShP7VDCX6KTv9L7sCn-7af0VfkirAly2QysoPEHduvpd7BOYNpY8</recordid><startdate>20150218</startdate><enddate>20150218</enddate><creator>Saina, Michael</creator><creator>Busengdal, Henriette</creator><creator>Sinigaglia, Chiara</creator><creator>Petrone, Libero</creator><creator>Oliveri, Paola</creator><creator>Rentzsch, Fabian</creator><creator>Benton, Richard</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150218</creationdate><title>A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning</title><author>Saina, Michael ; Busengdal, Henriette ; Sinigaglia, Chiara ; Petrone, Libero ; Oliveri, Paola ; Rentzsch, Fabian ; Benton, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-b3529b100e1069b0c0e52013c9e7fc261b81c168324d278e5347c5c0f027ecd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>13/51</topic><topic>13/95</topic><topic>14/34</topic><topic>38</topic><topic>38/23</topic><topic>38/39</topic><topic>38/77</topic><topic>631/136/1455</topic><topic>631/1647/2217/748</topic><topic>631/181</topic><topic>631/378/2626</topic><topic>96</topic><topic>Animals</topic><topic>Blastula - metabolism</topic><topic>Body Patterning</topic><topic>Chemoreceptor Cells - metabolism</topic><topic>Cloning, Molecular</topic><topic>Evolution, Molecular</topic><topic>Gastrula - metabolism</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genome</topic><topic>Genomics</topic><topic>Humanities and Social Sciences</topic><topic>Insect Proteins - metabolism</topic><topic>Insecta</topic><topic>multidisciplinary</topic><topic>Neurons - metabolism</topic><topic>Phylogeny</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sea Anemones - embryology</topic><topic>Sea Anemones - genetics</topic><topic>Sensory Receptor Cells - metabolism</topic><topic>Signal Transduction</topic><topic>Strongylocentrotus purpuratus - embryology</topic><topic>Strongylocentrotus purpuratus - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saina, Michael</creatorcontrib><creatorcontrib>Busengdal, Henriette</creatorcontrib><creatorcontrib>Sinigaglia, Chiara</creatorcontrib><creatorcontrib>Petrone, Libero</creatorcontrib><creatorcontrib>Oliveri, Paola</creatorcontrib><creatorcontrib>Rentzsch, Fabian</creatorcontrib><creatorcontrib>Benton, Richard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Saina, Michael</au><au>Busengdal, Henriette</au><au>Sinigaglia, Chiara</au><au>Petrone, Libero</au><au>Oliveri, Paola</au><au>Rentzsch, Fabian</au><au>Benton, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2015-02-18</date><risdate>2015</risdate><volume>6</volume><issue>1</issue><spage>6243</spage><epage>6243</epage><pages>6243-6243</pages><artnum>6243</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Insect gustatory and odorant receptors (GRs and ORs) form a superfamily of novel transmembrane proteins, which are expressed in chemosensory neurons that detect environmental stimuli. Here we identify homologues of
GR
s (
Gustatory receptor-like
(
Grl
) genes) in genomes across Protostomia, Deuterostomia and non-Bilateria. Surprisingly, two
Grls
in the cnidarian
Nematostella vectensis
,
NvecGrl1
and
NvecGrl2
, are expressed early in development, in the blastula and gastrula, but not at later stages when a putative chemosensory organ forms.
NvecGrl1
transcripts are detected around the aboral pole, considered the equivalent to the head-forming region of Bilateria. Morpholino-mediated knockdown of
NvecGrl1
causes developmental patterning defects of this region, leading to animals lacking the apical sensory organ. A deuterostome
Grl
from the sea urchin
Strongylocentrotus purpuratus
displays similar patterns of developmental expression. These results reveal an early evolutionary origin of the insect chemosensory receptor family and raise the possibility that their ancestral role was in embryonic development.
Insect gustatory and olfactory receptor genes encode transmembrane proteins that detect diverse chemicals, but their evolutionary origins are unclear. This study identifies homologues of these genes in non-Bilateria and reveals an unexpected role for one in sea anemone embryonic development.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25692633</pmid><doi>10.1038/ncomms7243</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature communications, 2015-02, Vol.6 (1), p.6243-6243, Article 6243 |
| issn | 2041-1723 2041-1723 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4374167 |
| source | Springer Nature OA Free Journals |
| subjects | 13/51 13/95 14/34 38 38/23 38/39 38/77 631/136/1455 631/1647/2217/748 631/181 631/378/2626 96 Animals Blastula - metabolism Body Patterning Chemoreceptor Cells - metabolism Cloning, Molecular Evolution, Molecular Gastrula - metabolism Gene Expression Regulation, Developmental Genome Genomics Humanities and Social Sciences Insect Proteins - metabolism Insecta multidisciplinary Neurons - metabolism Phylogeny Receptors, Cell Surface - metabolism Science Science (multidisciplinary) Sea Anemones - embryology Sea Anemones - genetics Sensory Receptor Cells - metabolism Signal Transduction Strongylocentrotus purpuratus - embryology Strongylocentrotus purpuratus - genetics |
| title | A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning |
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