Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder
Objectives Bipolar disorder (BD) is associated with cognitive dysfunction and structural brain abnormalities. In human and non‐human studies, lithium has been related to neuroprotective and neurotrophic effects. We explored whether lithium treatment is related to better brain integrity and cognitive...
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| Veröffentlicht in: | Bipolar disorders 2015-05, Vol.17 (3), p.248-256 |
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| container_title | Bipolar disorders |
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| creator | Gildengers, Ariel G Butters, Meryl A Aizenstein, Howard J Marron, Megan M Emanuel, James Anderson, Stewart J Weissfeld, Lisa A Becker, James T Lopez, Oscar L Mulsant, Benoit H Reynolds III, Charles F |
| description | Objectives
Bipolar disorder (BD) is associated with cognitive dysfunction and structural brain abnormalities. In human and non‐human studies, lithium has been related to neuroprotective and neurotrophic effects. We explored whether lithium treatment is related to better brain integrity and cognitive function in older adults with BD.
Methods
We examined cognitive and neuroimaging data in 58 individuals with BD [mean (standard deviation) age = 64.5 (9.8) years] and 21 mentally healthy comparators (controls) of similar age and education. Subjects received comprehensive neurocognitive assessment and structural brain imaging, examining total gray matter volume, overall white matter integrity (fractional anisotropy), and total white matter hyperintensity burden.
Results
In comparison to controls, subjects with BD had worse overall cognitive performance, lower total gray matter volume, and lower white matter integrity. Among subjects with BD, longer duration of lithium treatment was related to higher white matter integrity after controlling for age and vascular disease burden, but not with better cognitive performance.
Conclusions
Lithium treatment appears to be related to better brain integrity in older individuals with BD, in particular, in those who take lithium long‐term. While intriguing, these findings need to be confirmed in a larger sample. |
| doi_str_mv | 10.1111/bdi.12260 |
| format | Article |
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Bipolar disorder (BD) is associated with cognitive dysfunction and structural brain abnormalities. In human and non‐human studies, lithium has been related to neuroprotective and neurotrophic effects. We explored whether lithium treatment is related to better brain integrity and cognitive function in older adults with BD.
Methods
We examined cognitive and neuroimaging data in 58 individuals with BD [mean (standard deviation) age = 64.5 (9.8) years] and 21 mentally healthy comparators (controls) of similar age and education. Subjects received comprehensive neurocognitive assessment and structural brain imaging, examining total gray matter volume, overall white matter integrity (fractional anisotropy), and total white matter hyperintensity burden.
Results
In comparison to controls, subjects with BD had worse overall cognitive performance, lower total gray matter volume, and lower white matter integrity. Among subjects with BD, longer duration of lithium treatment was related to higher white matter integrity after controlling for age and vascular disease burden, but not with better cognitive performance.
Conclusions
Lithium treatment appears to be related to better brain integrity in older individuals with BD, in particular, in those who take lithium long‐term. While intriguing, these findings need to be confirmed in a larger sample.</description><identifier>ISSN: 1398-5647</identifier><identifier>EISSN: 1399-5618</identifier><identifier>DOI: 10.1111/bdi.12260</identifier><identifier>PMID: 25257942</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Aged ; Anisotropy ; Antimanic Agents - therapeutic use ; bipolar disorder ; Bipolar Disorder - drug therapy ; Bipolar Disorder - pathology ; Bipolar Disorder - psychology ; Brain - pathology ; Case-Control Studies ; Cognition ; Cognition Disorders - pathology ; Cognition Disorders - psychology ; Diffusion Tensor Imaging ; Female ; Gray Matter - pathology ; Humans ; lithium ; Lithium Compounds - therapeutic use ; Magnetic Resonance Imaging ; Male ; Middle Aged ; neuroprotection ; Neuropsychological Tests ; Time Factors ; Treatment Outcome ; White Matter - pathology</subject><ispartof>Bipolar disorders, 2015-05, Vol.17 (3), p.248-256</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5560-9de9b14dab4749d041b35e6fde4f6e6726b2fbdfe75c3414b6b7fd019514fcee3</citedby><cites>FETCH-LOGICAL-c5560-9de9b14dab4749d041b35e6fde4f6e6726b2fbdfe75c3414b6b7fd019514fcee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbdi.12260$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbdi.12260$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25257942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gildengers, Ariel G</creatorcontrib><creatorcontrib>Butters, Meryl A</creatorcontrib><creatorcontrib>Aizenstein, Howard J</creatorcontrib><creatorcontrib>Marron, Megan M</creatorcontrib><creatorcontrib>Emanuel, James</creatorcontrib><creatorcontrib>Anderson, Stewart J</creatorcontrib><creatorcontrib>Weissfeld, Lisa A</creatorcontrib><creatorcontrib>Becker, James T</creatorcontrib><creatorcontrib>Lopez, Oscar L</creatorcontrib><creatorcontrib>Mulsant, Benoit H</creatorcontrib><creatorcontrib>Reynolds III, Charles F</creatorcontrib><title>Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder</title><title>Bipolar disorders</title><addtitle>Bipolar Disord</addtitle><description>Objectives
Bipolar disorder (BD) is associated with cognitive dysfunction and structural brain abnormalities. In human and non‐human studies, lithium has been related to neuroprotective and neurotrophic effects. We explored whether lithium treatment is related to better brain integrity and cognitive function in older adults with BD.
Methods
We examined cognitive and neuroimaging data in 58 individuals with BD [mean (standard deviation) age = 64.5 (9.8) years] and 21 mentally healthy comparators (controls) of similar age and education. Subjects received comprehensive neurocognitive assessment and structural brain imaging, examining total gray matter volume, overall white matter integrity (fractional anisotropy), and total white matter hyperintensity burden.
Results
In comparison to controls, subjects with BD had worse overall cognitive performance, lower total gray matter volume, and lower white matter integrity. Among subjects with BD, longer duration of lithium treatment was related to higher white matter integrity after controlling for age and vascular disease burden, but not with better cognitive performance.
Conclusions
Lithium treatment appears to be related to better brain integrity in older individuals with BD, in particular, in those who take lithium long‐term. While intriguing, these findings need to be confirmed in a larger sample.</description><subject>Aged</subject><subject>Anisotropy</subject><subject>Antimanic Agents - therapeutic use</subject><subject>bipolar disorder</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - pathology</subject><subject>Bipolar Disorder - psychology</subject><subject>Brain - pathology</subject><subject>Case-Control Studies</subject><subject>Cognition</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - psychology</subject><subject>Diffusion Tensor Imaging</subject><subject>Female</subject><subject>Gray Matter - pathology</subject><subject>Humans</subject><subject>lithium</subject><subject>Lithium Compounds - therapeutic use</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>neuroprotection</subject><subject>Neuropsychological Tests</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>White Matter - pathology</subject><issn>1398-5647</issn><issn>1399-5618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhUcIREthwQugWcJiWtvjn3iDBAXa0ggWFCGxsezxncTgGQfbQ5q3xyRpBAuEJcvHvt89utapqqcYneKyzox1p5gQju5Vx7iVsmEcz-5v9axoKo6qRyl9QwhzgtjD6ogwwoSk5Lga52FcQKy9y0s3DTXcrkKaItQu1Tql0DmdwdbrUq4N5FzQ9dJlqAe9vbgxwyK6vCmqDt6WJ20nn9O-xa2C17G2LoVYio-rB732CZ7sz5Pq87u3N-eXzfzjxdX5q3nTMcZRIy1Ig6nVhgoqLaLYtAx4b4H2HLgg3JDe2B4E61qKqeFG9BZhyTDtO4D2pHq5811NZgDbwZij9moV3aDjRgXt1N-V0S3VIvxUtBUUUVIMnu8NYvgxQcpqcKkD7_UIYUoKz1pCqOQz_n-UC1Y2kbSgL3ZoF0NKEfrDRBip31GqEqXaRlnYZ39-4UDeZVeAsx2wdh42_3ZSr99c3Vk2uw6XMtweOnT8rrhoBVNfPlwofI0vP73_eqOu219g4br2</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Gildengers, Ariel G</creator><creator>Butters, Meryl A</creator><creator>Aizenstein, Howard J</creator><creator>Marron, Megan M</creator><creator>Emanuel, James</creator><creator>Anderson, Stewart J</creator><creator>Weissfeld, Lisa A</creator><creator>Becker, James T</creator><creator>Lopez, Oscar L</creator><creator>Mulsant, Benoit H</creator><creator>Reynolds III, Charles F</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201505</creationdate><title>Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder</title><author>Gildengers, Ariel G ; Butters, Meryl A ; Aizenstein, Howard J ; Marron, Megan M ; Emanuel, James ; Anderson, Stewart J ; Weissfeld, Lisa A ; Becker, James T ; Lopez, Oscar L ; Mulsant, Benoit H ; Reynolds III, Charles F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5560-9de9b14dab4749d041b35e6fde4f6e6726b2fbdfe75c3414b6b7fd019514fcee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Anisotropy</topic><topic>Antimanic Agents - therapeutic use</topic><topic>bipolar disorder</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - pathology</topic><topic>Bipolar Disorder - psychology</topic><topic>Brain - pathology</topic><topic>Case-Control Studies</topic><topic>Cognition</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - psychology</topic><topic>Diffusion Tensor Imaging</topic><topic>Female</topic><topic>Gray Matter - pathology</topic><topic>Humans</topic><topic>lithium</topic><topic>Lithium Compounds - therapeutic use</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>neuroprotection</topic><topic>Neuropsychological Tests</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gildengers, Ariel G</creatorcontrib><creatorcontrib>Butters, Meryl A</creatorcontrib><creatorcontrib>Aizenstein, Howard J</creatorcontrib><creatorcontrib>Marron, Megan M</creatorcontrib><creatorcontrib>Emanuel, James</creatorcontrib><creatorcontrib>Anderson, Stewart J</creatorcontrib><creatorcontrib>Weissfeld, Lisa A</creatorcontrib><creatorcontrib>Becker, James T</creatorcontrib><creatorcontrib>Lopez, Oscar L</creatorcontrib><creatorcontrib>Mulsant, Benoit H</creatorcontrib><creatorcontrib>Reynolds III, Charles F</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bipolar disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gildengers, Ariel G</au><au>Butters, Meryl A</au><au>Aizenstein, Howard J</au><au>Marron, Megan M</au><au>Emanuel, James</au><au>Anderson, Stewart J</au><au>Weissfeld, Lisa A</au><au>Becker, James T</au><au>Lopez, Oscar L</au><au>Mulsant, Benoit H</au><au>Reynolds III, Charles F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder</atitle><jtitle>Bipolar disorders</jtitle><addtitle>Bipolar Disord</addtitle><date>2015-05</date><risdate>2015</risdate><volume>17</volume><issue>3</issue><spage>248</spage><epage>256</epage><pages>248-256</pages><issn>1398-5647</issn><eissn>1399-5618</eissn><abstract>Objectives
Bipolar disorder (BD) is associated with cognitive dysfunction and structural brain abnormalities. In human and non‐human studies, lithium has been related to neuroprotective and neurotrophic effects. We explored whether lithium treatment is related to better brain integrity and cognitive function in older adults with BD.
Methods
We examined cognitive and neuroimaging data in 58 individuals with BD [mean (standard deviation) age = 64.5 (9.8) years] and 21 mentally healthy comparators (controls) of similar age and education. Subjects received comprehensive neurocognitive assessment and structural brain imaging, examining total gray matter volume, overall white matter integrity (fractional anisotropy), and total white matter hyperintensity burden.
Results
In comparison to controls, subjects with BD had worse overall cognitive performance, lower total gray matter volume, and lower white matter integrity. Among subjects with BD, longer duration of lithium treatment was related to higher white matter integrity after controlling for age and vascular disease burden, but not with better cognitive performance.
Conclusions
Lithium treatment appears to be related to better brain integrity in older individuals with BD, in particular, in those who take lithium long‐term. While intriguing, these findings need to be confirmed in a larger sample.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>25257942</pmid><doi>10.1111/bdi.12260</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1398-5647 |
| ispartof | Bipolar disorders, 2015-05, Vol.17 (3), p.248-256 |
| issn | 1398-5647 1399-5618 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4374042 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Aged Anisotropy Antimanic Agents - therapeutic use bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - pathology Bipolar Disorder - psychology Brain - pathology Case-Control Studies Cognition Cognition Disorders - pathology Cognition Disorders - psychology Diffusion Tensor Imaging Female Gray Matter - pathology Humans lithium Lithium Compounds - therapeutic use Magnetic Resonance Imaging Male Middle Aged neuroprotection Neuropsychological Tests Time Factors Treatment Outcome White Matter - pathology |
| title | Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder |
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