Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders

The proinflammatory cytokine osteopontin (OPN) is elevated in the cerebrospinal fluid (CSF) in individuals with HIV-associated neurocognitive disorders (HAND) and remains so in those on suppressive antiretroviral therapy. To understand the pathophysiological significance of elevated OPN in the CNS,...

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Veröffentlicht in:	Journal of neurovirology 2015-04, Vol.21 (2), p.174-185
Hauptverfasser:	Silva, Katie, Hope-Lucas, Calixto, White, Tyesha, Hairston, Tai-Kyung, Rameau, Tatenda, Brown, Amanda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Dementia Complex - complications AIDS Dementia Complex - metabolism Astrocytes - metabolism Biomedical and Life Sciences Biomedicine Cerebral Cortex - metabolism Cognition Disorders - etiology Cognition Disorders - metabolism Female Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunohistochemistry Immunology Infectious Diseases Macrophages - metabolism Male Microglia - metabolism Middle Aged Neurology Neurons - metabolism Neurosciences Oligonucleotide Array Sequence Analysis Osteopontin - biosynthesis Virology
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