Medullary regulation of visceral sympathetic nerve discharge at peak hyperthermia in aged F344 rats
Abstract Heat stress provides a potent stimulus for the activation of visceral sympathetic nerve discharge (SND) in young but not aged rats. Central mechanisms mediating attenuated SND responses to heating in aged rats have not been investigated. Because the GABAergic system in the rostral ventral l...
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| Veröffentlicht in: | Autonomic neuroscience 2014-12, Vol.186, p.32-37 |
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| description | Abstract Heat stress provides a potent stimulus for the activation of visceral sympathetic nerve discharge (SND) in young but not aged rats. Central mechanisms mediating attenuated SND responses to heating in aged rats have not been investigated. Because the GABAergic system in the rostral ventral lateral medulla (RVLM) is tonically inhibitory to SND, it is plausible to hypothesize that the withdrawal of RVLM GABA tone as a strategy to activate renal SND to heating is not engaged to the same degree in aged compared with young rats. The effect of bilateral RVLM disinhibition produced by bicuculline (BIC, GABAA receptor antagonist, 100 pmol) microinjections on renal SND in anesthetized young (3–6 months old) and aged (22–24 months old) Fischer 344 rats was determined after core body temperature (Tc) had been increased to 41.5 °C. Renal SND at 41.5 °C was significantly increased from control levels in young but not aged rats, whereas RVLM BIC microinjections at 41.5 °C produced marked renal sympathoexcitation in both groups. RVLM BIC microinjections at 38 °C in young and aged rats increased renal SND to similar levels as produced by RVLM BIC microinjections at 41.5 °C. The enhanced heating-induced renal sympathoactivation in young compared with aged rats; coupled with marked RVLM BIC-induced SND excitation under hyperthermic and normothermic conditions in both young and aged rats, suggests age-dependent changes in the withdrawal of RVLM GABA tone as a strategy to activate renal SND in response to acute heating. |
| doi_str_mv | 10.1016/j.autneu.2014.09.003 |
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Central mechanisms mediating attenuated SND responses to heating in aged rats have not been investigated. Because the GABAergic system in the rostral ventral lateral medulla (RVLM) is tonically inhibitory to SND, it is plausible to hypothesize that the withdrawal of RVLM GABA tone as a strategy to activate renal SND to heating is not engaged to the same degree in aged compared with young rats. The effect of bilateral RVLM disinhibition produced by bicuculline (BIC, GABAA receptor antagonist, 100 pmol) microinjections on renal SND in anesthetized young (3–6 months old) and aged (22–24 months old) Fischer 344 rats was determined after core body temperature (Tc) had been increased to 41.5 °C. Renal SND at 41.5 °C was significantly increased from control levels in young but not aged rats, whereas RVLM BIC microinjections at 41.5 °C produced marked renal sympathoexcitation in both groups. RVLM BIC microinjections at 38 °C in young and aged rats increased renal SND to similar levels as produced by RVLM BIC microinjections at 41.5 °C. The enhanced heating-induced renal sympathoactivation in young compared with aged rats; coupled with marked RVLM BIC-induced SND excitation under hyperthermic and normothermic conditions in both young and aged rats, suggests age-dependent changes in the withdrawal of RVLM GABA tone as a strategy to activate renal SND in response to acute heating.</description><identifier>ISSN: 1566-0702</identifier><identifier>EISSN: 1872-7484</identifier><identifier>DOI: 10.1016/j.autneu.2014.09.003</identifier><identifier>PMID: 25262958</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Advanced Basic Science ; Aged F344 rats ; Aging - physiology ; Animals ; Bicuculline ; Bicuculline - pharmacology ; Body Temperature - drug effects ; Body Temperature - physiology ; Fever - physiopathology ; GABA-A Receptor Antagonists - pharmacology ; gamma-Aminobutyric Acid - metabolism ; Heat stress ; Kidney - innervation ; Male ; Medical Education ; Medulla Oblongata - physiopathology ; Physical Stimulation ; Rats, Inbred F344 ; Receptors, GABA-A - metabolism ; Renal sympathetic nerve discharge ; RVLM ; Sympathetic Nervous System - physiopathology</subject><ispartof>Autonomic neuroscience, 2014-12, Vol.186, p.32-37</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><rights>2014 Published by Elsevier B.V. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-959b52d563a50b549eebc3ac2899a167290b9c68641eb702462d73c086fcd0e83</citedby><cites>FETCH-LOGICAL-c551t-959b52d563a50b549eebc3ac2899a167290b9c68641eb702462d73c086fcd0e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.autneu.2014.09.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25262958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kenney, M.J</creatorcontrib><title>Medullary regulation of visceral sympathetic nerve discharge at peak hyperthermia in aged F344 rats</title><title>Autonomic neuroscience</title><addtitle>Auton Neurosci</addtitle><description>Abstract Heat stress provides a potent stimulus for the activation of visceral sympathetic nerve discharge (SND) in young but not aged rats. Central mechanisms mediating attenuated SND responses to heating in aged rats have not been investigated. Because the GABAergic system in the rostral ventral lateral medulla (RVLM) is tonically inhibitory to SND, it is plausible to hypothesize that the withdrawal of RVLM GABA tone as a strategy to activate renal SND to heating is not engaged to the same degree in aged compared with young rats. The effect of bilateral RVLM disinhibition produced by bicuculline (BIC, GABAA receptor antagonist, 100 pmol) microinjections on renal SND in anesthetized young (3–6 months old) and aged (22–24 months old) Fischer 344 rats was determined after core body temperature (Tc) had been increased to 41.5 °C. Renal SND at 41.5 °C was significantly increased from control levels in young but not aged rats, whereas RVLM BIC microinjections at 41.5 °C produced marked renal sympathoexcitation in both groups. RVLM BIC microinjections at 38 °C in young and aged rats increased renal SND to similar levels as produced by RVLM BIC microinjections at 41.5 °C. The enhanced heating-induced renal sympathoactivation in young compared with aged rats; coupled with marked RVLM BIC-induced SND excitation under hyperthermic and normothermic conditions in both young and aged rats, suggests age-dependent changes in the withdrawal of RVLM GABA tone as a strategy to activate renal SND in response to acute heating.</description><subject>Advanced Basic Science</subject><subject>Aged F344 rats</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Bicuculline</subject><subject>Bicuculline - pharmacology</subject><subject>Body Temperature - drug effects</subject><subject>Body Temperature - physiology</subject><subject>Fever - physiopathology</subject><subject>GABA-A Receptor Antagonists - pharmacology</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Heat stress</subject><subject>Kidney - innervation</subject><subject>Male</subject><subject>Medical Education</subject><subject>Medulla Oblongata - physiopathology</subject><subject>Physical Stimulation</subject><subject>Rats, Inbred F344</subject><subject>Receptors, GABA-A - metabolism</subject><subject>Renal sympathetic nerve discharge</subject><subject>RVLM</subject><subject>Sympathetic Nervous System - physiopathology</subject><issn>1566-0702</issn><issn>1872-7484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAQjRCIlsI_QMhHLgnjz8QXJFS1UKmIA3C2HGd219t8YTsr7b_H0ZZSuMDJlubNm3nvTVG8plBRoOrdvrJLGnGpGFBRga4A-JPinDY1K2vRiKf5L5UqoQZ2VryIcQ8ADWj1vDhjkimmZXNeuM_YLX1vw5EE3C69TX4aybQhBx8dBtuTeBxmm3aYvCMjhgOSLpd2NmyR2ERmtHdkd5wxZEwYvCV-JHaLHbnmQpBgU3xZPNvYPuKr-_ei-H599e3yU3n75ePN5Yfb0klJU6mlbiXrpOJWQiuFRmwdt441Wluqaqah1U41SlBssyihWFdzB43auA6w4RfF-xPvvLQDdg7HlAWYOfgh6zOT9ebPyuh3ZjsdjOA1rZs6E7y9JwjTjwVjMsPqQrZnxGmJhiqR53Kpm_-AMq0V4_UKFSeoC1OMATcPG1Ewa5Rmb05RmjVKA9rkKHPbm8dqHpp-ZfdbLmZPDx6Dic7j6LDzAV0y3eT_NeFvAtf70Tvb3-ER435awpjzMtREZsB8Xc9pvSYqACjPJvwEQDPHlA</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Kenney, M.J</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20141201</creationdate><title>Medullary regulation of visceral sympathetic nerve discharge at peak hyperthermia in aged F344 rats</title><author>Kenney, M.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-959b52d563a50b549eebc3ac2899a167290b9c68641eb702462d73c086fcd0e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Advanced Basic Science</topic><topic>Aged F344 rats</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Bicuculline</topic><topic>Bicuculline - pharmacology</topic><topic>Body Temperature - drug effects</topic><topic>Body Temperature - physiology</topic><topic>Fever - physiopathology</topic><topic>GABA-A Receptor Antagonists - pharmacology</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Heat stress</topic><topic>Kidney - innervation</topic><topic>Male</topic><topic>Medical Education</topic><topic>Medulla Oblongata - physiopathology</topic><topic>Physical Stimulation</topic><topic>Rats, Inbred F344</topic><topic>Receptors, GABA-A - metabolism</topic><topic>Renal sympathetic nerve discharge</topic><topic>RVLM</topic><topic>Sympathetic Nervous System - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kenney, M.J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Autonomic neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kenney, M.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medullary regulation of visceral sympathetic nerve discharge at peak hyperthermia in aged F344 rats</atitle><jtitle>Autonomic neuroscience</jtitle><addtitle>Auton Neurosci</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>186</volume><spage>32</spage><epage>37</epage><pages>32-37</pages><issn>1566-0702</issn><eissn>1872-7484</eissn><abstract>Abstract Heat stress provides a potent stimulus for the activation of visceral sympathetic nerve discharge (SND) in young but not aged rats. Central mechanisms mediating attenuated SND responses to heating in aged rats have not been investigated. Because the GABAergic system in the rostral ventral lateral medulla (RVLM) is tonically inhibitory to SND, it is plausible to hypothesize that the withdrawal of RVLM GABA tone as a strategy to activate renal SND to heating is not engaged to the same degree in aged compared with young rats. The effect of bilateral RVLM disinhibition produced by bicuculline (BIC, GABAA receptor antagonist, 100 pmol) microinjections on renal SND in anesthetized young (3–6 months old) and aged (22–24 months old) Fischer 344 rats was determined after core body temperature (Tc) had been increased to 41.5 °C. Renal SND at 41.5 °C was significantly increased from control levels in young but not aged rats, whereas RVLM BIC microinjections at 41.5 °C produced marked renal sympathoexcitation in both groups. RVLM BIC microinjections at 38 °C in young and aged rats increased renal SND to similar levels as produced by RVLM BIC microinjections at 41.5 °C. The enhanced heating-induced renal sympathoactivation in young compared with aged rats; coupled with marked RVLM BIC-induced SND excitation under hyperthermic and normothermic conditions in both young and aged rats, suggests age-dependent changes in the withdrawal of RVLM GABA tone as a strategy to activate renal SND in response to acute heating.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25262958</pmid><doi>10.1016/j.autneu.2014.09.003</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Advanced Basic Science Aged F344 rats Aging - physiology Animals Bicuculline Bicuculline - pharmacology Body Temperature - drug effects Body Temperature - physiology Fever - physiopathology GABA-A Receptor Antagonists - pharmacology gamma-Aminobutyric Acid - metabolism Heat stress Kidney - innervation Male Medical Education Medulla Oblongata - physiopathology Physical Stimulation Rats, Inbred F344 Receptors, GABA-A - metabolism Renal sympathetic nerve discharge RVLM Sympathetic Nervous System - physiopathology |
| title | Medullary regulation of visceral sympathetic nerve discharge at peak hyperthermia in aged F344 rats |
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