Population pharmacokinetics of ampicillin and sulbactam in patients with community‐acquired pneumonia: evaluation of the impact of renal impairment

Aims The aims of this study were to develop a population pharmacokinetic (PK) model of ampicillin and sulbactam, to identify patient characteristics influencing the PK, and to explore the relationship between dose regimen and degree of renal impairment with exposure and time above minimum inhibitory...

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Veröffentlicht in:	British journal of clinical pharmacology 2014-03, Vol.77 (3), p.509-521
Hauptverfasser:	Soto, Elena, Shoji, Satoshi, Muto, Chieko, Tomono, Yoshiro, Marshall, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over ampicillin Ampicillin - administration & dosage Ampicillin - blood Ampicillin - pharmacokinetics Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Community-Acquired Infections - blood Community-Acquired Infections - complications Community-Acquired Infections - drug therapy Community-Acquired Infections - microbiology Computer Simulation Drug Administration Schedule Drug Combinations Drug Dosage Calculations Female Humans Infusions, Intravenous Japan Kidney - physiopathology Kidney Diseases - blood Kidney Diseases - complications Kidney Diseases - physiopathology Male Metabolic Clearance Rate Microbial Sensitivity Tests Middle Aged Models, Biological Pharmacokinetics pneumonia Pneumonia, Bacterial - blood Pneumonia, Bacterial - complications Pneumonia, Bacterial - drug therapy Pneumonia, Bacterial - microbiology population pharmacokinetics sulbactam Sulbactam - administration & dosage Sulbactam - blood Sulbactam - pharmacokinetics Unasyn
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