Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study

A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in indepe...

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Veröffentlicht in:	Genes and immunity 2015-03, Vol.16 (2), p.142-150
Hauptverfasser:	Martins, M, Williams, A H, Comeau, M, Marion, M, Ziegler, J T, Freedman, B I, Merrill, J T, Glenn, S B, Kelly, J A, Sivils, K M, James, J A, Guthridge, J M, Alarcón-Riquelme, M E, Bae, S-C, Kim, J-H, Kim, D, Anaya, J-M, Boackle, S A, Criswell, L A, Kimberly, R P, Alarcón, G S, Brown, E E, Vilá, L M, Petri, M A, Ramsey-Goldman, R, Niewold, T B, Tsao, B P, Gilkeson, G S, Kamen, D L, Jacob, C O, Stevens, A M, Gaffney, P M, Harley, J B, Langefeld, C D, Fesel, C
Format:	Artikel
Sprache:	eng
Schlagworte:	45 631/208/205 Adult Analysis Asian Continental Ancestry Group - genetics Association analysis Autoimmune diseases Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Case-Control Studies CD3 Complex - genetics Diagnosis European Continental Ancestry Group - genetics Female Gene Expression Gene frequency Genetic analysis Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Haplotypes Health aspects Human Genetics Humans Immunology Lupus Erythematosus, Systemic - ethnology Lupus Erythematosus, Systemic - genetics Lymphocytes T Male original-article Phenotypes Polymorphism, Single Nucleotide Population genetics Single nucleotide polymorphisms Single-nucleotide polymorphism Systemic lupus erythematosus T cell receptors T cells T-Lymphocytes - immunology
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