Combination of methamphetamine and HIV-1 gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system

Methamphetamine (METH) abuse is frequent in individuals infected with human immunodeficiency virus type-1 (HIV-1) and is suspected to aggravate HIV-associated neurocognitive disorders (HAND). METH is a psychostimulant that compromises several neurotransmitter systems and HIV proteins trigger neurona...

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Veröffentlicht in:	Experimental neurology 2015-01, Vol.263, p.221-234
Hauptverfasser:	Hoefer, Melanie M., Sanchez, Ana B., Maung, Ricky, de Rozieres, Cyrus M., Catalan, Irene C., Dowling, Cari C., Thaney, Victoria E., Piña-Crespo, Juan, Zhang, Dongxian, Roberts, Amanda J., Kaul, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior Behavior, Animal - drug effects Brain - drug effects Brain - pathology Brain - virology Central Nervous System Stimulants - adverse effects Electrophysiology Gene expression HIV Envelope Protein gp120 HIV Infections - complications HIV-1 HIV-1 gp120 Human immunodeficiency virus Human immunodeficiency virus 1 Immunohistochemistry Methamphetamine Methamphetamine - adverse effects Mice Mice, Transgenic NeuroAIDS Neuropathology Patch-Clamp Techniques Reverse Transcriptase Polymerase Chain Reaction Substance-Related Disorders - complications Transcriptome - drug effects Transgenic animal model
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