NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer

NEDD9 is an established marker of invasive and metastatic cancers. NEDD9 downregulation has been shown to dramatically reduce cell invasion and metastasis in multiple tumors. The mechanisms by which NEDD9 regulates invasion are largely unknown. In the current study, we have found that NEDD9 is requi...

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Veröffentlicht in:	Oncogene 2015-07, Vol.34 (28), p.3662-3675
Hauptverfasser:	Loskutov, Y V, Kozyulina, P Y, Kozyreva, V K, Ice, R J, Jones, B C, Roston, T J, Smolkin, M B, Ivanov, A V, Wysolmerski, R B, Pugacheva, E N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism ADP-ribosylation factor ADP-Ribosylation Factors - metabolism Animals Antisense therapy Apoptosis Biomarkers Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer metastasis Cell adhesion & migration Cell Biology Cell Line, Tumor Cell Movement Development and progression Endosomes Endosomes - metabolism Enzyme regulation Female Genetic aspects GTPase-activating protein Guanosine triphosphatases Health aspects HEK293 Cells Human Genetics Humans Internal Medicine Invasiveness Matrix Matrix metalloproteinase Matrix Metalloproteinase 14 - metabolism Medicine Medicine & Public Health Mesenchyme Mesoderm - cytology Mesoderm - pathology Metalloproteinase Metastases Metastasis Mice Neoplasm Metastasis Neoplasm Transplantation Oligonucleotides, Antisense - pharmacology Oncology original-article Phosphoproteins - metabolism Properties Proteases Protein transport Protein turnover Proteins Signal Transduction Therapeutic applications Tissue inhibitor of metalloproteinase 2 Tissue Inhibitor of Metalloproteinase-2 - metabolism Tumor cells Tumors Xenografts
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