Myelopathy following intrathecal chemotherapy in adults: a single institution experience

Methotrexate and cytarabine arabinoside are frequently administered intrathecally in the prophylaxis and treatment of patients with hematological malignancies. Myelopathy as a complication of intrathecal (IT) chemotherapy is rare in adults, with most of the cases described in the literature occurrin...

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Veröffentlicht in:	Journal of neuro-oncology 2015-04, Vol.122 (2), p.391-398
Hauptverfasser:	Cachia, David, Kamiya-Matsuoka, Carlos, Pinnix, Chelsea C., Chi, Linda, Kantarjian, Hagop M., Cortes, Jorge E., Daver, Naval, Woodman, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Clinical Study Cytarabine - administration & dosage Cytarabine - adverse effects Female Humans Injections, Spinal - adverse effects Leukemia, B-Cell - complications Leukemia, B-Cell - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Methotrexate - administration & dosage Methotrexate - adverse effects Middle Aged Myelin Basic Protein - metabolism Neurology Oncology Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Spinal Cord - drug effects Spinal Cord - pathology Spinal Cord Diseases - chemically induced Spinal Cord Diseases - pathology Spinal Cord Diseases - physiopathology
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