A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation

Lysine-specific demethylase 1 (LSD1) has been reported to repress and activate transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively. The molecular mechanism that underlies this dual substrate specificity has remained unknown. Here we report that an isoform of LSD1,...

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Veröffentlicht in:	Molecular cell 2015-03, Vol.57 (6), p.957-970
Hauptverfasser:	Laurent, Benoit, Ruitu, Lv, Murn, Jernej, Hempel, Kristina, Ferrao, Ryan, Xiang, Yang, Liu, Shichong, Garcia, Benjamin A., Wu, Hao, Wu, Feizhen, Steen, Hanno, Shi, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Cell Differentiation Cell Movement Gene Expression Regulation Gene Knockdown Techniques HeLa Cells Histone Demethylases - genetics Histone Demethylases - metabolism Histones - genetics Histones - metabolism Humans Lysine - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Methylation Microfilament Proteins - genetics Microfilament Proteins - metabolism Neurons - cytology Neurons - metabolism Promoter Regions, Genetic Protein Isoforms - metabolism
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