Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway

Programmed −1 ribosomal frameshift (−1 PRF) signals redirect translating ribosomes to slip back one base on messenger RNAs. Although well characterized in viruses, how these elements may regulate cellular gene expression is not understood. Here we describe a −1 PRF signal in the human mRNA encoding...

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Veröffentlicht in:	Nature (London) 2014-08, Vol.512 (7514), p.265-269
Hauptverfasser:	Belew, Ashton Trey, Meskauskas, Arturas, Musalgaonkar, Sharmishtha, Advani, Vivek M., Sulima, Sergey O., Kasprzak, Wojciech K., Shapiro, Bruce A., Dinman, Jonathan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 13/106 13/109 13/89 38/1 38/44 38/70 38/71 38/77 38/90 42 631/250/98 631/337/384/331 82/58 82/81 82/83 Amino Acid Sequence Base Sequence Binding Sites Cell Survival Cellular control mechanisms Codon, Nonsense - genetics Cytokine receptors Cytokines Decay Frameshifting, Ribosomal - genetics Gene expression Genetic aspects Genetic research Health aspects HeLa Cells Humanities and Social Sciences Humans Messenger RNA MicroRNAs - genetics Models, Molecular Molecular Sequence Data Monkeys & apes multidisciplinary Nonsense Mediated mRNA Decay Nucleic Acid Conformation Peptides Proteins Receptors, CCR5 - genetics Receptors, Interleukin - genetics Regulatory Sequences, Ribonucleic Acid Ribonucleic acid Ribosomal proteins Ribosomal RNA Ribosomes - metabolism RNA RNA processing RNA viruses RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism Science Structure
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