Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative
Fluorescence of hematoporphyrin derivative (HPD) has been used clinically to localize malignant neoplasms because of its selective accumulation in these tissues. We tested the hypothesis that HPD may also be selectively concentrated within atheromatous plaques. 48 h after HPD injection in a variety...
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| Veröffentlicht in: | The Journal of clinical investigation 1983-02, Vol.71 (2), p.395-399 |
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| container_title | The Journal of clinical investigation |
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| creator | Spears, J R Serur, J Shropshire, D Paulin, S |
| description | Fluorescence of hematoporphyrin derivative (HPD) has been used clinically to localize malignant neoplasms because of its selective accumulation in these tissues. We tested the hypothesis that HPD may also be selectively concentrated within atheromatous plaques. 48 h after HPD injection in a variety of species, selective fluorescence of atheromatous plaques of the aorta was seen in each animal (rabbits and Patas monkey) exhibiting such lesions. No fluorescence could be demonstrated in aortic segments free of atheromatous involvement. Since the efficacy of photodynamic destruction of malignant tumors with HPD has been demonstrated in clinical studies, the observations of the present study may have therapeutic implications in atheromatosis. |
| doi_str_mv | 10.1172/JCI110782 |
| format | Article |
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We tested the hypothesis that HPD may also be selectively concentrated within atheromatous plaques. 48 h after HPD injection in a variety of species, selective fluorescence of atheromatous plaques of the aorta was seen in each animal (rabbits and Patas monkey) exhibiting such lesions. No fluorescence could be demonstrated in aortic segments free of atheromatous involvement. Since the efficacy of photodynamic destruction of malignant tumors with HPD has been demonstrated in clinical studies, the observations of the present study may have therapeutic implications in atheromatosis.</description><identifier>ISSN: 0021-9738</identifier><identifier>DOI: 10.1172/JCI110782</identifier><identifier>PMID: 6822671</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Aorta - analysis ; Aorta - pathology ; Arteriosclerosis - metabolism ; Arteriosclerosis - pathology ; Chickens ; Dogs ; Erythrocebus patas ; Female ; Guinea Pigs ; Hematoporphyrins - administration & dosage ; Hematoporphyrins - analysis ; Male ; Microscopy, Fluorescence ; Rabbits ; Rats ; Rats, Inbred Strains</subject><ispartof>The Journal of clinical investigation, 1983-02, Vol.71 (2), p.395-399</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-82485e31f1fef5c7bf4784f7f85f66aaba35ea9c0f3ec02de118e69081b93c6a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC436880/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC436880/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6822671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spears, J R</creatorcontrib><creatorcontrib>Serur, J</creatorcontrib><creatorcontrib>Shropshire, D</creatorcontrib><creatorcontrib>Paulin, S</creatorcontrib><title>Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>Fluorescence of hematoporphyrin derivative (HPD) has been used clinically to localize malignant neoplasms because of its selective accumulation in these tissues. We tested the hypothesis that HPD may also be selectively concentrated within atheromatous plaques. 48 h after HPD injection in a variety of species, selective fluorescence of atheromatous plaques of the aorta was seen in each animal (rabbits and Patas monkey) exhibiting such lesions. No fluorescence could be demonstrated in aortic segments free of atheromatous involvement. Since the efficacy of photodynamic destruction of malignant tumors with HPD has been demonstrated in clinical studies, the observations of the present study may have therapeutic implications in atheromatosis.</description><subject>Animals</subject><subject>Aorta - analysis</subject><subject>Aorta - pathology</subject><subject>Arteriosclerosis - metabolism</subject><subject>Arteriosclerosis - pathology</subject><subject>Chickens</subject><subject>Dogs</subject><subject>Erythrocebus patas</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Hematoporphyrins - administration & dosage</subject><subject>Hematoporphyrins - analysis</subject><subject>Male</subject><subject>Microscopy, Fluorescence</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0021-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkD9PwzAQxT2ASikMfACkTEgMAf9JHGdgQBWFokoICWbLcc8kKI2D7RT67XHVqoLppLvfu7v3ELog-IaQgt4-T-eE4ELQIzTGmJK0LJg4Qafef2JMsizPRmjEBaW8IGP0OmsH68Br6DQk1iTw04NrVtAF1SYq1ODsSgU7-KRv1dcAPvluQp3UsO321vX1xjVdsoyitQrNGs7QsVGth_N9naD32cPb9CldvDzOp_eLVDNehlTQTOTAiCEGTK6LymSFyExhRG44V6pSLAdVamwYaEyXQIgAXmJBqpJprtgE3e329kO1gmU0EJxqZR-fV24jrWrk_0nX1PLDrmXGuBA46q_2eme3voJcNTGGtlUdRLsyIrkglETwegdqZ713YA43CJbbyOUh8she_n3qQO7zZr8BlYGj</recordid><startdate>19830201</startdate><enddate>19830201</enddate><creator>Spears, J R</creator><creator>Serur, J</creator><creator>Shropshire, D</creator><creator>Paulin, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19830201</creationdate><title>Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative</title><author>Spears, J R ; Serur, J ; Shropshire, D ; Paulin, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-82485e31f1fef5c7bf4784f7f85f66aaba35ea9c0f3ec02de118e69081b93c6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Aorta - analysis</topic><topic>Aorta - pathology</topic><topic>Arteriosclerosis - metabolism</topic><topic>Arteriosclerosis - pathology</topic><topic>Chickens</topic><topic>Dogs</topic><topic>Erythrocebus patas</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Hematoporphyrins - administration & dosage</topic><topic>Hematoporphyrins - analysis</topic><topic>Male</topic><topic>Microscopy, Fluorescence</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spears, J R</creatorcontrib><creatorcontrib>Serur, J</creatorcontrib><creatorcontrib>Shropshire, D</creatorcontrib><creatorcontrib>Paulin, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spears, J R</au><au>Serur, J</au><au>Shropshire, D</au><au>Paulin, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1983-02-01</date><risdate>1983</risdate><volume>71</volume><issue>2</issue><spage>395</spage><epage>399</epage><pages>395-399</pages><issn>0021-9738</issn><abstract>Fluorescence of hematoporphyrin derivative (HPD) has been used clinically to localize malignant neoplasms because of its selective accumulation in these tissues. We tested the hypothesis that HPD may also be selectively concentrated within atheromatous plaques. 48 h after HPD injection in a variety of species, selective fluorescence of atheromatous plaques of the aorta was seen in each animal (rabbits and Patas monkey) exhibiting such lesions. No fluorescence could be demonstrated in aortic segments free of atheromatous involvement. Since the efficacy of photodynamic destruction of malignant tumors with HPD has been demonstrated in clinical studies, the observations of the present study may have therapeutic implications in atheromatosis.</abstract><cop>United States</cop><pmid>6822671</pmid><doi>10.1172/JCI110782</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of clinical investigation, 1983-02, Vol.71 (2), p.395-399 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Aorta - analysis Aorta - pathology Arteriosclerosis - metabolism Arteriosclerosis - pathology Chickens Dogs Erythrocebus patas Female Guinea Pigs Hematoporphyrins - administration & dosage Hematoporphyrins - analysis Male Microscopy, Fluorescence Rabbits Rats Rats, Inbred Strains |
| title | Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative |
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