Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: a meta-analysis based on 51 case-control studies
Studies and systematic reviews have reached inconsistent conclusions on the role of 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphism C677T in acute lymphoblastic leukemia (ALL) risk. The present meta-analysis comprising of 51 case-control studies, including 7892 cases and 14 280 contro...
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| Veröffentlicht in: | Medical science monitor 2015-03, Vol.21, p.740-748 |
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| description | Studies and systematic reviews have reached inconsistent conclusions on the role of 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphism C677T in acute lymphoblastic leukemia (ALL) risk.
The present meta-analysis comprising of 51 case-control studies, including 7892 cases and 14 280 controls was performed to reevaluate the association between MTHFR C677T polymorphism and ALL risk.
Statistical differences were found in the dominant model (TT+CT vs. CC, odd ratio (OR)=0.89, 95% CI, 0.79-1.00, P=0.04) and the CT vs. CC (OR=0.89, 95% CI, 0.80-1.00, P=0.05), but not in the allele contrast model (T vs. C, OR=0.92, 95% CI, 0.84-1.01, P=0.08), additive model (TT vs. CC, OR=0.87, 95% CI, 0.73-1.05, P=0.15), or recessive model (TT vs. CT+CC, OR=0.94, 95% CI, 0.81-1.10, P=0.44) in overall populations. In the subgroup analyses stratified by age (children and adults) and ethnicity (Asian and Caucasian), no significant associations between MTHFR C677T polymorphism and ALL risk were observed.
The current study found no sufficient evidence of a protective role of MTHFR C677T polymorphism in ALL susceptibility. |
| doi_str_mv | 10.12659/MSM.892835 |
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The present meta-analysis comprising of 51 case-control studies, including 7892 cases and 14 280 controls was performed to reevaluate the association between MTHFR C677T polymorphism and ALL risk.
Statistical differences were found in the dominant model (TT+CT vs. CC, odd ratio (OR)=0.89, 95% CI, 0.79-1.00, P=0.04) and the CT vs. CC (OR=0.89, 95% CI, 0.80-1.00, P=0.05), but not in the allele contrast model (T vs. C, OR=0.92, 95% CI, 0.84-1.01, P=0.08), additive model (TT vs. CC, OR=0.87, 95% CI, 0.73-1.05, P=0.15), or recessive model (TT vs. CT+CC, OR=0.94, 95% CI, 0.81-1.10, P=0.44) in overall populations. In the subgroup analyses stratified by age (children and adults) and ethnicity (Asian and Caucasian), no significant associations between MTHFR C677T polymorphism and ALL risk were observed.
The current study found no sufficient evidence of a protective role of MTHFR C677T polymorphism in ALL susceptibility.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.892835</identifier><identifier>PMID: 25761797</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Age Factors ; Case-Control Studies ; Ethnic Groups - genetics ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Meta-Analysis ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Polymorphism, Single Nucleotide - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Publication Bias ; Risk Factors</subject><ispartof>Medical science monitor, 2015-03, Vol.21, p.740-748</ispartof><rights>Med Sci Monit, 2015 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-625c95f16ef4b69c857976e7efc65a1f14518c5ffdb759936c67caa09014f133</citedby><cites>FETCH-LOGICAL-c381t-625c95f16ef4b69c857976e7efc65a1f14518c5ffdb759936c67caa09014f133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368066/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368066/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25761797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Su-yi</creatorcontrib><creatorcontrib>Ye, Jie-yu</creatorcontrib><creatorcontrib>Liang, En-yu</creatorcontrib><creatorcontrib>Zhou, Li-xia</creatorcontrib><creatorcontrib>Yang, Mo</creatorcontrib><title>Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: a meta-analysis based on 51 case-control studies</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>Studies and systematic reviews have reached inconsistent conclusions on the role of 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphism C677T in acute lymphoblastic leukemia (ALL) risk.
The present meta-analysis comprising of 51 case-control studies, including 7892 cases and 14 280 controls was performed to reevaluate the association between MTHFR C677T polymorphism and ALL risk.
Statistical differences were found in the dominant model (TT+CT vs. CC, odd ratio (OR)=0.89, 95% CI, 0.79-1.00, P=0.04) and the CT vs. CC (OR=0.89, 95% CI, 0.80-1.00, P=0.05), but not in the allele contrast model (T vs. C, OR=0.92, 95% CI, 0.84-1.01, P=0.08), additive model (TT vs. CC, OR=0.87, 95% CI, 0.73-1.05, P=0.15), or recessive model (TT vs. CT+CC, OR=0.94, 95% CI, 0.81-1.10, P=0.44) in overall populations. In the subgroup analyses stratified by age (children and adults) and ethnicity (Asian and Caucasian), no significant associations between MTHFR C677T polymorphism and ALL risk were observed.
The current study found no sufficient evidence of a protective role of MTHFR C677T polymorphism in ALL susceptibility.</description><subject>Age Factors</subject><subject>Case-Control Studies</subject><subject>Ethnic Groups - genetics</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Meta-Analysis</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Publication Bias</subject><subject>Risk Factors</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUFv1DAQhS0EoqVw4o58REIpdhzbCQekakUpUldIsHfLccasqROHjAPaX9C_XYstVTnNSO_Tmzd6hLzm7JzXSnbvt9-3521Xt0I-IadcNaISWrKnj_YT8gLxJ2N1q5h8Tk5qqRXXnT4ltxeIyQWbQ5poD_kPwES3u6vLb3SjtN7ROcXDmJZ5H3CkdhroEvCGJk-tWzPQIs771EeLOTgaYb2BMdgP1NIRsq3sZOMBA9LeIgy03JCcurJXLk15SZFiXocA-JI88zYivLqfZ2R3-Wm3uaquv37-srm4rpxoea5ULV0nPVfgm151rpXlCwUavFPScs8byVsnvR96LbtOKKe0s5Z1jDeeC3FGPh5t57UfYXBQQtho5iWMdjmYZIP5X5nC3vxIv00jVMuUKgZv7w2W9GsFzGYM6CBGO0Fa0fDCKNlKxQr67oi6JSEu4B_OcGb-NmdKc-bYXKHfPE72wP6rStwBYhKV9A</recordid><startdate>20150312</startdate><enddate>20150312</enddate><creator>Li, Su-yi</creator><creator>Ye, Jie-yu</creator><creator>Liang, En-yu</creator><creator>Zhou, Li-xia</creator><creator>Yang, Mo</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150312</creationdate><title>Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: a meta-analysis based on 51 case-control studies</title><author>Li, Su-yi ; Ye, Jie-yu ; Liang, En-yu ; Zhou, Li-xia ; Yang, Mo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-625c95f16ef4b69c857976e7efc65a1f14518c5ffdb759936c67caa09014f133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age Factors</topic><topic>Case-Control Studies</topic><topic>Ethnic Groups - genetics</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Meta-Analysis</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Publication Bias</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Su-yi</creatorcontrib><creatorcontrib>Ye, Jie-yu</creatorcontrib><creatorcontrib>Liang, En-yu</creatorcontrib><creatorcontrib>Zhou, Li-xia</creatorcontrib><creatorcontrib>Yang, Mo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Su-yi</au><au>Ye, Jie-yu</au><au>Liang, En-yu</au><au>Zhou, Li-xia</au><au>Yang, Mo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: a meta-analysis based on 51 case-control studies</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2015-03-12</date><risdate>2015</risdate><volume>21</volume><spage>740</spage><epage>748</epage><pages>740-748</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>Studies and systematic reviews have reached inconsistent conclusions on the role of 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphism C677T in acute lymphoblastic leukemia (ALL) risk.
The present meta-analysis comprising of 51 case-control studies, including 7892 cases and 14 280 controls was performed to reevaluate the association between MTHFR C677T polymorphism and ALL risk.
Statistical differences were found in the dominant model (TT+CT vs. CC, odd ratio (OR)=0.89, 95% CI, 0.79-1.00, P=0.04) and the CT vs. CC (OR=0.89, 95% CI, 0.80-1.00, P=0.05), but not in the allele contrast model (T vs. C, OR=0.92, 95% CI, 0.84-1.01, P=0.08), additive model (TT vs. CC, OR=0.87, 95% CI, 0.73-1.05, P=0.15), or recessive model (TT vs. CT+CC, OR=0.94, 95% CI, 0.81-1.10, P=0.44) in overall populations. In the subgroup analyses stratified by age (children and adults) and ethnicity (Asian and Caucasian), no significant associations between MTHFR C677T polymorphism and ALL risk were observed.
The current study found no sufficient evidence of a protective role of MTHFR C677T polymorphism in ALL susceptibility.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>25761797</pmid><doi>10.12659/MSM.892835</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Case-Control Studies Ethnic Groups - genetics Genetic Association Studies Genetic Predisposition to Disease Humans Meta-Analysis Methylenetetrahydrofolate Reductase (NADPH2) - genetics Polymorphism, Single Nucleotide - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Publication Bias Risk Factors |
| title | Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: a meta-analysis based on 51 case-control studies |
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