Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients

Background: PPM1D (WIP1) negatively regulates by dephosphorylation many proteins including p53 tumour suppressor. The truncating mutations (nonsense and frameshift) in exon 6 of PPM1D were found recently in blood cells of patients with breast, ovarian or colorectal cancer. These mutants code for gai...

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Veröffentlicht in:	British journal of cancer 2015-03, Vol.112 (6), p.1114-1120
Hauptverfasser:	Zajkowicz, A, Butkiewicz, D, Drosik, A, Giglok, M, Suwiński, R, Rusin, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 631/337/458/1733 692/699/67/1612/1350 692/699/67/68 Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - genetics Codon, Nonsense DNA Damage DNA, Neoplasm - blood DNA, Neoplasm - genetics Drug Resistance Epidemiology Exons Female Frameshift Mutation Genetics and Genomics Humans Lung cancer Lung Neoplasms - blood Lung Neoplasms - genetics Male Middle Aged Molecular Medicine Oncology Phosphoprotein Phosphatases - blood Phosphoprotein Phosphatases - genetics Promoter Regions, Genetic Protein Phosphatase 2C Serine - genetics Tumor Suppressor Protein p53 - genetics Young Adult
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