Potassium and glucose measures in older adults: the Cardiovascular Health Study
We sought to determine the impacts of serum and dietary potassium measures on glucose metabolism and diabetes risk in older adults. Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2015-02, Vol.70 (2), p.255-261 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Chatterjee, Ranee Biggs, Mary L de Boer, Ian H Brancati, Frederick L Svetkey, Laura P Barzilay, Joshua Djoussé, Luc Ix, Joachim H Kizer, Jorge R Siscovick, David S Mozaffarian, Dariush Edelman, David Mukamal, Kenneth J |
| description | We sought to determine the impacts of serum and dietary potassium measures on glucose metabolism and diabetes risk in older adults.
Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium and measures of insulin sensitivity and secretion estimated from oral glucose tolerance tests and b) longitudinal associations of serum and dietary potassium with diabetes risk.
Among 4,754 participants aged ≥65 years at baseline, there were 445 cases of incident diabetes during a median follow-up of 12 years. In multivariate models, baseline serum and dietary potassium were both associated with lower insulin sensitivity and greater insulin secretion. Compared with those with a serum potassium ≥4.5 mEq/L, participants with a serum potassium |
| doi_str_mv | 10.1093/gerona/glu071 |
| format | Article |
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Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium and measures of insulin sensitivity and secretion estimated from oral glucose tolerance tests and b) longitudinal associations of serum and dietary potassium with diabetes risk.
Among 4,754 participants aged ≥65 years at baseline, there were 445 cases of incident diabetes during a median follow-up of 12 years. In multivariate models, baseline serum and dietary potassium were both associated with lower insulin sensitivity and greater insulin secretion. Compared with those with a serum potassium ≥4.5 mEq/L, participants with a serum potassium <4.0mEq/L had an adjusted mean difference in Matsuda insulin sensitivity index of -0.18 (-0.39, 0.02). Compared with those in the highest quartile, participants in the lowest quartile of dietary potassium intake had a corresponding adjusted mean difference in Matsuda insulin sensitivity index of -0.61 (-0.94, -0.29). In multivariate models, neither serum nor dietary potassium intake was associated with long-term diabetes risk.
Although we did not identify serum and dietary potassium as risk factors for incident diabetes in older adults, results from cross-sectional analyses suggest that both may be associated with increased insulin resistance. This relationship with insulin resistance needs to be confirmed, and its importance on diabetes risk, cardiovascular risk, and conditions specific to older adults should be determined as well.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glu071</identifier><identifier>PMID: 24895271</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Blood Glucose - analysis ; Cardiovascular system ; Cohort Studies ; Cross-Sectional Studies ; Diabetes Mellitus - blood ; Diabetes Mellitus - epidemiology ; Female ; Glucose ; Humans ; Insulin - blood ; Insulin Resistance ; Longitudinal Studies ; Male ; Multivariate Analysis ; Older people ; Potassium ; Potassium - blood ; Potassium, Dietary - administration & dosage ; Risk Factors ; Sensitivity analysis ; United States - epidemiology</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2015-02, Vol.70 (2), p.255-261</ispartof><rights>The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press, UK Feb 2015</rights><rights>The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-9378de8b58013079021ffe427fd7895e8d2e38d7e3f5d236cd4dd3b1cd2687383</citedby><cites>FETCH-LOGICAL-c415t-9378de8b58013079021ffe427fd7895e8d2e38d7e3f5d236cd4dd3b1cd2687383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24895271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chatterjee, Ranee</creatorcontrib><creatorcontrib>Biggs, Mary L</creatorcontrib><creatorcontrib>de Boer, Ian H</creatorcontrib><creatorcontrib>Brancati, Frederick L</creatorcontrib><creatorcontrib>Svetkey, Laura P</creatorcontrib><creatorcontrib>Barzilay, Joshua</creatorcontrib><creatorcontrib>Djoussé, Luc</creatorcontrib><creatorcontrib>Ix, Joachim H</creatorcontrib><creatorcontrib>Kizer, Jorge R</creatorcontrib><creatorcontrib>Siscovick, David S</creatorcontrib><creatorcontrib>Mozaffarian, Dariush</creatorcontrib><creatorcontrib>Edelman, David</creatorcontrib><creatorcontrib>Mukamal, Kenneth J</creatorcontrib><title>Potassium and glucose measures in older adults: the Cardiovascular Health Study</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>We sought to determine the impacts of serum and dietary potassium measures on glucose metabolism and diabetes risk in older adults.
Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium and measures of insulin sensitivity and secretion estimated from oral glucose tolerance tests and b) longitudinal associations of serum and dietary potassium with diabetes risk.
Among 4,754 participants aged ≥65 years at baseline, there were 445 cases of incident diabetes during a median follow-up of 12 years. In multivariate models, baseline serum and dietary potassium were both associated with lower insulin sensitivity and greater insulin secretion. Compared with those with a serum potassium ≥4.5 mEq/L, participants with a serum potassium <4.0mEq/L had an adjusted mean difference in Matsuda insulin sensitivity index of -0.18 (-0.39, 0.02). Compared with those in the highest quartile, participants in the lowest quartile of dietary potassium intake had a corresponding adjusted mean difference in Matsuda insulin sensitivity index of -0.61 (-0.94, -0.29). In multivariate models, neither serum nor dietary potassium intake was associated with long-term diabetes risk.
Although we did not identify serum and dietary potassium as risk factors for incident diabetes in older adults, results from cross-sectional analyses suggest that both may be associated with increased insulin resistance. This relationship with insulin resistance needs to be confirmed, and its importance on diabetes risk, cardiovascular risk, and conditions specific to older adults should be determined as well.</description><subject>Aged</subject><subject>Blood Glucose - analysis</subject><subject>Cardiovascular system</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Female</subject><subject>Glucose</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Older people</subject><subject>Potassium</subject><subject>Potassium - blood</subject><subject>Potassium, Dietary - administration & dosage</subject><subject>Risk Factors</subject><subject>Sensitivity analysis</subject><subject>United States - epidemiology</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtLxDAUhYMovpduJeDGTTWPpkldCDL4AkFBBXch09zOVNJGk2bAf2-GUVHv5l64H4dzOAgdUHJCSc1PZxD8YE5nLhFJ19A2lUIVgouX9XwTWReCkGoL7cT4SpYj2CbaYqWqBZN0G90_-NHE2KUem8HiLNP4CLgHE1OAiLsBe2chYGOTG-MZHueAJybYzi9MbJIzAd-AceMcP47Jfuyhjda4CPtfexc9X10-TW6Ku_vr28nFXdGUVIxFzaWyoKZCEcqzS8Jo20LJZGtltgbKMuDKSuCtsIxXjS2t5VPaWFYpyRXfRecr3bc07cE2MIzBOP0Wut6ED-1Np_9-hm6uZ36hS15Voq6zwPGXQPDvCeKo-y424JwZwKeoaSUYr4VgZUaP_qGvPoUhx1tSlDBG6ypTxYpqgo8xQPtjhhK9rEqvqtKrqjJ_-DvBD_3dDf8E8rSSSw</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Chatterjee, Ranee</creator><creator>Biggs, Mary L</creator><creator>de Boer, Ian H</creator><creator>Brancati, Frederick L</creator><creator>Svetkey, Laura P</creator><creator>Barzilay, Joshua</creator><creator>Djoussé, Luc</creator><creator>Ix, Joachim H</creator><creator>Kizer, Jorge R</creator><creator>Siscovick, David S</creator><creator>Mozaffarian, Dariush</creator><creator>Edelman, David</creator><creator>Mukamal, Kenneth J</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Potassium and glucose measures in older adults: the Cardiovascular Health Study</title><author>Chatterjee, Ranee ; Biggs, Mary L ; de Boer, Ian H ; Brancati, Frederick L ; Svetkey, Laura P ; Barzilay, Joshua ; Djoussé, Luc ; Ix, Joachim H ; Kizer, Jorge R ; Siscovick, David S ; Mozaffarian, Dariush ; Edelman, David ; Mukamal, Kenneth J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-9378de8b58013079021ffe427fd7895e8d2e38d7e3f5d236cd4dd3b1cd2687383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Blood Glucose - analysis</topic><topic>Cardiovascular system</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Female</topic><topic>Glucose</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Older people</topic><topic>Potassium</topic><topic>Potassium - blood</topic><topic>Potassium, Dietary - administration & dosage</topic><topic>Risk Factors</topic><topic>Sensitivity analysis</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chatterjee, Ranee</creatorcontrib><creatorcontrib>Biggs, Mary L</creatorcontrib><creatorcontrib>de Boer, Ian H</creatorcontrib><creatorcontrib>Brancati, Frederick L</creatorcontrib><creatorcontrib>Svetkey, Laura P</creatorcontrib><creatorcontrib>Barzilay, Joshua</creatorcontrib><creatorcontrib>Djoussé, Luc</creatorcontrib><creatorcontrib>Ix, Joachim H</creatorcontrib><creatorcontrib>Kizer, Jorge R</creatorcontrib><creatorcontrib>Siscovick, David S</creatorcontrib><creatorcontrib>Mozaffarian, Dariush</creatorcontrib><creatorcontrib>Edelman, David</creatorcontrib><creatorcontrib>Mukamal, Kenneth J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chatterjee, Ranee</au><au>Biggs, Mary L</au><au>de Boer, Ian H</au><au>Brancati, Frederick L</au><au>Svetkey, Laura P</au><au>Barzilay, Joshua</au><au>Djoussé, Luc</au><au>Ix, Joachim H</au><au>Kizer, Jorge R</au><au>Siscovick, David S</au><au>Mozaffarian, Dariush</au><au>Edelman, David</au><au>Mukamal, Kenneth J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potassium and glucose measures in older adults: the Cardiovascular Health Study</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>70</volume><issue>2</issue><spage>255</spage><epage>261</epage><pages>255-261</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>We sought to determine the impacts of serum and dietary potassium measures on glucose metabolism and diabetes risk in older adults.
Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium and measures of insulin sensitivity and secretion estimated from oral glucose tolerance tests and b) longitudinal associations of serum and dietary potassium with diabetes risk.
Among 4,754 participants aged ≥65 years at baseline, there were 445 cases of incident diabetes during a median follow-up of 12 years. In multivariate models, baseline serum and dietary potassium were both associated with lower insulin sensitivity and greater insulin secretion. Compared with those with a serum potassium ≥4.5 mEq/L, participants with a serum potassium <4.0mEq/L had an adjusted mean difference in Matsuda insulin sensitivity index of -0.18 (-0.39, 0.02). Compared with those in the highest quartile, participants in the lowest quartile of dietary potassium intake had a corresponding adjusted mean difference in Matsuda insulin sensitivity index of -0.61 (-0.94, -0.29). In multivariate models, neither serum nor dietary potassium intake was associated with long-term diabetes risk.
Although we did not identify serum and dietary potassium as risk factors for incident diabetes in older adults, results from cross-sectional analyses suggest that both may be associated with increased insulin resistance. This relationship with insulin resistance needs to be confirmed, and its importance on diabetes risk, cardiovascular risk, and conditions specific to older adults should be determined as well.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>24895271</pmid><doi>10.1093/gerona/glu071</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2015-02, Vol.70 (2), p.255-261 |
| issn | 1079-5006 1758-535X |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Blood Glucose - analysis Cardiovascular system Cohort Studies Cross-Sectional Studies Diabetes Mellitus - blood Diabetes Mellitus - epidemiology Female Glucose Humans Insulin - blood Insulin Resistance Longitudinal Studies Male Multivariate Analysis Older people Potassium Potassium - blood Potassium, Dietary - administration & dosage Risk Factors Sensitivity analysis United States - epidemiology |
| title | Potassium and glucose measures in older adults: the Cardiovascular Health Study |
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