Visual outcome and incidence of glaucoma in patients with microspherophakia
Introduction A number of ocular complications have been reported in microspherophakia. The literature however is limited to small case reports and the incidence of these complications is largely unknown. Our study describes a series of patients who presented to our hospital from 1998 to 2008. Materi...
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| Veröffentlicht in: | Eye (London) 2015-03, Vol.29 (3), p.350-355 |
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| creator | Muralidhar, R Ankush, K Vijayalakshmi, P George, V P |
| description | Introduction
A number of ocular complications have been reported in microspherophakia. The literature however is limited to small case reports and the incidence of these complications is largely unknown. Our study describes a series of patients who presented to our hospital from 1998 to 2008.
Material and methods
Data on the clinical and surgical findings of patients presented to us from 1998 to 2008 with microspherophakia were retrieved from the medical records and the results analyzed.
Results
Thirty-six eyes of 18 patients were reviewed. The mean age at presentation was 16±10 years. All patients had varying degrees of lenticular myopia with a mean of −11.07±5.03 D. Glaucoma developed in 16 eyes (44.4%). Half of them had high IOP at presentation. Despite medical and surgical management IOP remained high in five eyes at the last follow-up. Sixteen eyes (44.4%) required lensectomy for dislocated crystalline lens. Lensectomy did not have any impact on the intraocular pressures. Homocysteinuria was the most common systemic association noted.
Conclusion
Microspherophakia is associated with a high incidence of lenticular myopia, subluxation of the crystalline lens and glaucoma. Management of glaucoma is difficult with the IOP remaining high in spite of combined medical and surgical management. |
| doi_str_mv | 10.1038/eye.2014.250 |
| format | Article |
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A number of ocular complications have been reported in microspherophakia. The literature however is limited to small case reports and the incidence of these complications is largely unknown. Our study describes a series of patients who presented to our hospital from 1998 to 2008.
Material and methods
Data on the clinical and surgical findings of patients presented to us from 1998 to 2008 with microspherophakia were retrieved from the medical records and the results analyzed.
Results
Thirty-six eyes of 18 patients were reviewed. The mean age at presentation was 16±10 years. All patients had varying degrees of lenticular myopia with a mean of −11.07±5.03 D. Glaucoma developed in 16 eyes (44.4%). Half of them had high IOP at presentation. Despite medical and surgical management IOP remained high in five eyes at the last follow-up. Sixteen eyes (44.4%) required lensectomy for dislocated crystalline lens. Lensectomy did not have any impact on the intraocular pressures. Homocysteinuria was the most common systemic association noted.
Conclusion
Microspherophakia is associated with a high incidence of lenticular myopia, subluxation of the crystalline lens and glaucoma. Management of glaucoma is difficult with the IOP remaining high in spite of combined medical and surgical management.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2014.250</identifier><identifier>PMID: 25397784</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/3161/3168 ; Adolescent ; Adult ; Child ; Child, Preschool ; Clinical Study ; Corneal Diseases - complications ; Corneal Diseases - physiopathology ; Ectopia Lentis - complications ; Ectopia Lentis - physiopathology ; Filtering Surgery ; Glaucoma ; Glaucoma - complications ; Glaucoma - etiology ; Glaucoma - physiopathology ; Glaucoma - surgery ; Homocystinuria - diagnosis ; Homocystinuria - etiology ; Humans ; Incidence ; Intraocular Pressure ; Iris - abnormalities ; Iris - physiopathology ; Laboratory Medicine ; Lens Subluxation - etiology ; Lens Subluxation - surgery ; Medicine ; Medicine & Public Health ; Myopia - etiology ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Surgery ; Surgical Oncology ; Tonometry, Ocular ; Visual Acuity - physiology ; Young Adult</subject><ispartof>Eye (London), 2015-03, Vol.29 (3), p.350-355</ispartof><rights>Royal College of Ophthalmologists 2015</rights><rights>Copyright Nature Publishing Group Mar 2015</rights><rights>Copyright © 2015 Royal College of Ophthalmologists 2015 Royal College of Ophthalmologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-bf6751916f64a0428d655bdb8694a74e96d2af98c7ba0047d4c6cfd976b446f43</citedby><cites>FETCH-LOGICAL-c520t-bf6751916f64a0428d655bdb8694a74e96d2af98c7ba0047d4c6cfd976b446f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366451/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366451/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25397784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muralidhar, R</creatorcontrib><creatorcontrib>Ankush, K</creatorcontrib><creatorcontrib>Vijayalakshmi, P</creatorcontrib><creatorcontrib>George, V P</creatorcontrib><title>Visual outcome and incidence of glaucoma in patients with microspherophakia</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Introduction
A number of ocular complications have been reported in microspherophakia. The literature however is limited to small case reports and the incidence of these complications is largely unknown. Our study describes a series of patients who presented to our hospital from 1998 to 2008.
Material and methods
Data on the clinical and surgical findings of patients presented to us from 1998 to 2008 with microspherophakia were retrieved from the medical records and the results analyzed.
Results
Thirty-six eyes of 18 patients were reviewed. The mean age at presentation was 16±10 years. All patients had varying degrees of lenticular myopia with a mean of −11.07±5.03 D. Glaucoma developed in 16 eyes (44.4%). Half of them had high IOP at presentation. Despite medical and surgical management IOP remained high in five eyes at the last follow-up. Sixteen eyes (44.4%) required lensectomy for dislocated crystalline lens. Lensectomy did not have any impact on the intraocular pressures. Homocysteinuria was the most common systemic association noted.
Conclusion
Microspherophakia is associated with a high incidence of lenticular myopia, subluxation of the crystalline lens and glaucoma. Management of glaucoma is difficult with the IOP remaining high in spite of combined medical and surgical management.</description><subject>692/699/3161/3168</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Study</subject><subject>Corneal Diseases - complications</subject><subject>Corneal Diseases - physiopathology</subject><subject>Ectopia Lentis - complications</subject><subject>Ectopia Lentis - physiopathology</subject><subject>Filtering Surgery</subject><subject>Glaucoma</subject><subject>Glaucoma - complications</subject><subject>Glaucoma - etiology</subject><subject>Glaucoma - physiopathology</subject><subject>Glaucoma - surgery</subject><subject>Homocystinuria - diagnosis</subject><subject>Homocystinuria - etiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intraocular Pressure</subject><subject>Iris - abnormalities</subject><subject>Iris - physiopathology</subject><subject>Laboratory Medicine</subject><subject>Lens Subluxation - etiology</subject><subject>Lens Subluxation - surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myopia - etiology</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tonometry, Ocular</subject><subject>Visual Acuity - physiology</subject><subject>Young Adult</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkc9r2zAYhsVYWdOut56LYZcd6kySpU_WZVDC-oMGetnGbkKW5USZbXmS3dL_vgpJSzt6Euh9ePV9ehA6JXhOcFF-s492TjFhc8rxBzQjTEDOGWcf0QxLjnNK6Z9DdBTjBidKCPwJHVJeSCFKNkO3v12cdJv5aTS-s5nu68z1xtW2NzbzTbZq9ZQSnW6zQY_O9mPMHty4zjpngo_D2gY_rPVfpz-jg0a30Z7sz2P06_LHz8V1vry7ullcLHPDKR7zqgHBiSTQANOY0bIGzqu6KkEyLZiVUFPdyNKISmPMRM0MmKaWAirGoGHFMfq-6x2mqrO1SSMF3aohuE6HR-W1U2-T3q3Vyt8rVgAwTlLB131B8P8mG0fVuWhs2-re-ikqAlAAB-AioV_-Qzd-Cn1ab0sJkCUVMlHnO2r7IzHY5mUYgtXWkkqW1NaSSpYSfvZ6gRf4WUsC8h0QU9SvbHj16nuFT702nYE</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Muralidhar, R</creator><creator>Ankush, K</creator><creator>Vijayalakshmi, P</creator><creator>George, V P</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150301</creationdate><title>Visual outcome and incidence of glaucoma in patients with microspherophakia</title><author>Muralidhar, R ; Ankush, K ; Vijayalakshmi, P ; George, V P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-bf6751916f64a0428d655bdb8694a74e96d2af98c7ba0047d4c6cfd976b446f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/699/3161/3168</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Study</topic><topic>Corneal Diseases - complications</topic><topic>Corneal Diseases - physiopathology</topic><topic>Ectopia Lentis - complications</topic><topic>Ectopia Lentis - physiopathology</topic><topic>Filtering Surgery</topic><topic>Glaucoma</topic><topic>Glaucoma - complications</topic><topic>Glaucoma - etiology</topic><topic>Glaucoma - physiopathology</topic><topic>Glaucoma - surgery</topic><topic>Homocystinuria - diagnosis</topic><topic>Homocystinuria - etiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intraocular Pressure</topic><topic>Iris - abnormalities</topic><topic>Iris - physiopathology</topic><topic>Laboratory Medicine</topic><topic>Lens Subluxation - etiology</topic><topic>Lens Subluxation - surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myopia - etiology</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tonometry, Ocular</topic><topic>Visual Acuity - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muralidhar, R</creatorcontrib><creatorcontrib>Ankush, K</creatorcontrib><creatorcontrib>Vijayalakshmi, P</creatorcontrib><creatorcontrib>George, V P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muralidhar, R</au><au>Ankush, K</au><au>Vijayalakshmi, P</au><au>George, V P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual outcome and incidence of glaucoma in patients with microspherophakia</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>29</volume><issue>3</issue><spage>350</spage><epage>355</epage><pages>350-355</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Introduction
A number of ocular complications have been reported in microspherophakia. The literature however is limited to small case reports and the incidence of these complications is largely unknown. Our study describes a series of patients who presented to our hospital from 1998 to 2008.
Material and methods
Data on the clinical and surgical findings of patients presented to us from 1998 to 2008 with microspherophakia were retrieved from the medical records and the results analyzed.
Results
Thirty-six eyes of 18 patients were reviewed. The mean age at presentation was 16±10 years. All patients had varying degrees of lenticular myopia with a mean of −11.07±5.03 D. Glaucoma developed in 16 eyes (44.4%). Half of them had high IOP at presentation. Despite medical and surgical management IOP remained high in five eyes at the last follow-up. Sixteen eyes (44.4%) required lensectomy for dislocated crystalline lens. Lensectomy did not have any impact on the intraocular pressures. Homocysteinuria was the most common systemic association noted.
Conclusion
Microspherophakia is associated with a high incidence of lenticular myopia, subluxation of the crystalline lens and glaucoma. Management of glaucoma is difficult with the IOP remaining high in spite of combined medical and surgical management.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25397784</pmid><doi>10.1038/eye.2014.250</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/699/3161/3168 Adolescent Adult Child Child, Preschool Clinical Study Corneal Diseases - complications Corneal Diseases - physiopathology Ectopia Lentis - complications Ectopia Lentis - physiopathology Filtering Surgery Glaucoma Glaucoma - complications Glaucoma - etiology Glaucoma - physiopathology Glaucoma - surgery Homocystinuria - diagnosis Homocystinuria - etiology Humans Incidence Intraocular Pressure Iris - abnormalities Iris - physiopathology Laboratory Medicine Lens Subluxation - etiology Lens Subluxation - surgery Medicine Medicine & Public Health Myopia - etiology Ophthalmology Pharmaceutical Sciences/Technology Surgery Surgical Oncology Tonometry, Ocular Visual Acuity - physiology Young Adult |
| title | Visual outcome and incidence of glaucoma in patients with microspherophakia |
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