Sequential activation of splenic nuclear RNA polymerases by erythropoietin

The spleen of the ex-hypoxic polycythemic mouse was employed to study the effect of erythropoietin on nuclear RNA polymerase activity. On the basis of ionic strength requirements and sensitivity to the fungal toxin alpha-amanitin, two major forms (I and II) of nuclear RNA polymerase were identified....

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Veröffentlicht in:	The Journal of clinical investigation 1976-01, Vol.57 (1), p.20-26
Hauptverfasser:	Piantadosi, C A, Dickerman, H W, Spivak, J L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - enzymology DNA-Directed RNA Polymerases - metabolism Enzyme Activation Erythroblasts - drug effects Erythroblasts - physiology Erythropoiesis Erythropoietin - pharmacology Female Mice Polycythemia - etiology Polycythemia - physiopathology Spleen - drug effects Spleen - enzymology Transcription, Genetic
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