Sex differences in skeletal muscle Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: A cross-sectional study
Women have higher adiposity but maintain insulin sensitivity when compared to men. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibits insulin signaling, but it is not known if PTEN regulate insulin resistance in a sex-specific manner. In this cross-sectional study, muscle biopsi...
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| Veröffentlicht in: | Scientific reports 2015-03, Vol.5 (1), p.9154-9154, Article 9154 |
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| description | Women have higher adiposity but maintain insulin sensitivity when compared to men. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibits insulin signaling, but it is not known if PTEN regulate insulin resistance in a sex-specific manner. In this cross-sectional study, muscle biopsies from participants in the Molecular Study of Health and Risk in Ethnic Groups (Mol-SHARE) were used to test for sex differences in PTEN expression. Quantitative real-time PCR was performed to determine PTEN gene expression (n = 53) and western blotting detected total and phosphorylated PTEN protein (n = 36). Study participants were comparable in age and body mass index. Women had higher fat mass percentage compared to men (40.25 ± 9.9% in women versus 27.6 ± 8.8% in men; mean difference −0.18, 95%CI (−0.24, −0.11), p-value |
| doi_str_mv | 10.1038/srep09154 |
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Constantine ; Anand, Sonia S. ; Sharma, Arya M. ; Samjoo, Imtiaz A. ; Tarnopolsky, Mark A.</creator><creatorcontrib>Samaan, M. Constantine ; Anand, Sonia S. ; Sharma, Arya M. ; Samjoo, Imtiaz A. ; Tarnopolsky, Mark A.</creatorcontrib><description>Women have higher adiposity but maintain insulin sensitivity when compared to men. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibits insulin signaling, but it is not known if PTEN regulate insulin resistance in a sex-specific manner. In this cross-sectional study, muscle biopsies from participants in the Molecular Study of Health and Risk in Ethnic Groups (Mol-SHARE) were used to test for sex differences in PTEN expression. Quantitative real-time PCR was performed to determine PTEN gene expression (n = 53) and western blotting detected total and phosphorylated PTEN protein (n = 36). Study participants were comparable in age and body mass index. Women had higher fat mass percentage compared to men (40.25 ± 9.9% in women versus 27.6 ± 8.8% in men; mean difference −0.18, 95%CI (−0.24, −0.11), p-value <0.0001), with similar HOMA-IR (2.46 ± 2.05 in men versus 2.34 ± 3.06 in women; mean difference 0.04; 95% CI (−0.12, 0.21), p-value 0.59). Women had significant downregulation of PTEN gene expression (p-value 0.01) and upregulation of PTEN protein phosphorylation (inactivation) (p-value 0.001) when compared to men after correction for age, ethnicity, HOMA-IR, fat mass and sex. We conclude that the downregulation of muscle PTEN may explain the retention of insulin sensitivity with higher adiposity in women compared to men.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep09154</identifier><identifier>PMID: 25777795</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/95 ; 38 ; 38/88 ; 631/337 ; 631/80 ; 692/308/1892 ; 692/53 ; 82 ; Adipose tissue ; Adipose Tissue - anatomy & histology ; Adipose Tissue - metabolism ; Adult ; Body fat ; Body mass ; Body mass index ; Chromosome 10 ; Cross-Sectional Studies ; Female ; Gender differences ; Gene Expression ; Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism ; Humanities and Social Sciences ; Humans ; Inactivation ; Insulin ; Insulin resistance ; Male ; Minority & ethnic groups ; multidisciplinary ; Muscle, Skeletal - metabolism ; Organ Size ; Phenotype ; Phosphatase ; Phosphorylation ; Polymerase chain reaction ; PTEN Phosphohydrolase - genetics ; PTEN Phosphohydrolase - metabolism ; PTEN protein ; Risk Factors ; Science ; Sex differences ; Sex Factors ; Skeletal muscle ; Tensin ; Western blotting ; Young Adult</subject><ispartof>Scientific reports, 2015-03, Vol.5 (1), p.9154-9154, Article 9154</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Mar 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited. All rights reserved 2015 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-c7ddfd9bc2ffe49758874272508b30fe928e89a57f7519ff634523ad93810823</citedby><cites>FETCH-LOGICAL-c504t-c7ddfd9bc2ffe49758874272508b30fe928e89a57f7519ff634523ad93810823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366049/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366049/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,41125,42194,51581,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25777795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samaan, M. Constantine</creatorcontrib><creatorcontrib>Anand, Sonia S.</creatorcontrib><creatorcontrib>Sharma, Arya M.</creatorcontrib><creatorcontrib>Samjoo, Imtiaz A.</creatorcontrib><creatorcontrib>Tarnopolsky, Mark A.</creatorcontrib><title>Sex differences in skeletal muscle Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: A cross-sectional study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Women have higher adiposity but maintain insulin sensitivity when compared to men. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibits insulin signaling, but it is not known if PTEN regulate insulin resistance in a sex-specific manner. In this cross-sectional study, muscle biopsies from participants in the Molecular Study of Health and Risk in Ethnic Groups (Mol-SHARE) were used to test for sex differences in PTEN expression. Quantitative real-time PCR was performed to determine PTEN gene expression (n = 53) and western blotting detected total and phosphorylated PTEN protein (n = 36). Study participants were comparable in age and body mass index. Women had higher fat mass percentage compared to men (40.25 ± 9.9% in women versus 27.6 ± 8.8% in men; mean difference −0.18, 95%CI (−0.24, −0.11), p-value <0.0001), with similar HOMA-IR (2.46 ± 2.05 in men versus 2.34 ± 3.06 in women; mean difference 0.04; 95% CI (−0.12, 0.21), p-value 0.59). Women had significant downregulation of PTEN gene expression (p-value 0.01) and upregulation of PTEN protein phosphorylation (inactivation) (p-value 0.001) when compared to men after correction for age, ethnicity, HOMA-IR, fat mass and sex. We conclude that the downregulation of muscle PTEN may explain the retention of insulin sensitivity with higher adiposity in women compared to men.</description><subject>13</subject><subject>13/95</subject><subject>38</subject><subject>38/88</subject><subject>631/337</subject><subject>631/80</subject><subject>692/308/1892</subject><subject>692/53</subject><subject>82</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - anatomy & histology</subject><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Body fat</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Chromosome 10</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gender differences</subject><subject>Gene Expression</subject><subject>Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inactivation</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Male</subject><subject>Minority & ethnic groups</subject><subject>multidisciplinary</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Organ Size</subject><subject>Phenotype</subject><subject>Phosphatase</subject><subject>Phosphorylation</subject><subject>Polymerase chain reaction</subject><subject>PTEN Phosphohydrolase - genetics</subject><subject>PTEN Phosphohydrolase - metabolism</subject><subject>PTEN protein</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Skeletal muscle</subject><subject>Tensin</subject><subject>Western blotting</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkV9rFDEUxQdRbKl98AtIwJdWGM3fmcQHoZRWhaIF933IJnd2p2aSNXem2Ee_eVO3Lqvel3vJ_XFyklNVLxl9y6jQ7zDDhhqm5JPqkFOpai44f7o3H1THiDe0lOJGMvO8OuCqLWXUYfXrG_wkfuh7yBAdIBkiwe8QYLKBjDO6AOR6nXCztpNFIDZ6MkHEgq3TmEJaEf9AgycpErfO5RDTCIRRcnK9uPhySgLcQsD35Iy4nBBrBDcNKRZ9nGZ_96J61tuAcPzYj6rF5cXi_FN99fXj5_Ozq9opKqfatd733iwdL16laZXWreQtV1QvBe3BcA3aWNX2rWKm7xshFRfWG6EZ1VwcVR-2spt5OYJ3EKdsQ7fJw2jzXZfs0P29icO6W6XbToqmodIUgZNHgZx-zIBTNw7oIAQbIc3YsaaRUnKtWUFf_4PepDmXFxdKG90I0RpRqNMt9ftbMvQ7M4x2D9F2u2gL-2rf_Y78E2QB3mwBLKu4grx35X9q9z1jrjQ</recordid><startdate>20150317</startdate><enddate>20150317</enddate><creator>Samaan, M. 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Constantine</creatorcontrib><creatorcontrib>Anand, Sonia S.</creatorcontrib><creatorcontrib>Sharma, Arya M.</creatorcontrib><creatorcontrib>Samjoo, Imtiaz A.</creatorcontrib><creatorcontrib>Tarnopolsky, Mark A.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samaan, M. Constantine</au><au>Anand, Sonia S.</au><au>Sharma, Arya M.</au><au>Samjoo, Imtiaz A.</au><au>Tarnopolsky, Mark A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in skeletal muscle Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: A cross-sectional study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-03-17</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>9154</spage><epage>9154</epage><pages>9154-9154</pages><artnum>9154</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Women have higher adiposity but maintain insulin sensitivity when compared to men. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibits insulin signaling, but it is not known if PTEN regulate insulin resistance in a sex-specific manner. In this cross-sectional study, muscle biopsies from participants in the Molecular Study of Health and Risk in Ethnic Groups (Mol-SHARE) were used to test for sex differences in PTEN expression. Quantitative real-time PCR was performed to determine PTEN gene expression (n = 53) and western blotting detected total and phosphorylated PTEN protein (n = 36). Study participants were comparable in age and body mass index. Women had higher fat mass percentage compared to men (40.25 ± 9.9% in women versus 27.6 ± 8.8% in men; mean difference −0.18, 95%CI (−0.24, −0.11), p-value <0.0001), with similar HOMA-IR (2.46 ± 2.05 in men versus 2.34 ± 3.06 in women; mean difference 0.04; 95% CI (−0.12, 0.21), p-value 0.59). Women had significant downregulation of PTEN gene expression (p-value 0.01) and upregulation of PTEN protein phosphorylation (inactivation) (p-value 0.001) when compared to men after correction for age, ethnicity, HOMA-IR, fat mass and sex. We conclude that the downregulation of muscle PTEN may explain the retention of insulin sensitivity with higher adiposity in women compared to men.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25777795</pmid><doi>10.1038/srep09154</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13 13/95 38 38/88 631/337 631/80 692/308/1892 692/53 82 Adipose tissue Adipose Tissue - anatomy & histology Adipose Tissue - metabolism Adult Body fat Body mass Body mass index Chromosome 10 Cross-Sectional Studies Female Gender differences Gene Expression Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Humanities and Social Sciences Humans Inactivation Insulin Insulin resistance Male Minority & ethnic groups multidisciplinary Muscle, Skeletal - metabolism Organ Size Phenotype Phosphatase Phosphorylation Polymerase chain reaction PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein Risk Factors Science Sex differences Sex Factors Skeletal muscle Tensin Western blotting Young Adult |
| title | Sex differences in skeletal muscle Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: A cross-sectional study |
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