Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway

Toll-like receptors (TLR) constitute a highly conserved class of receptors through which the innate immune system responds to both pathogen- and host-derived factors. Although TLRs are involved in a wide range of central nervous system (CNS) disorders including neurodegenerative diseases, the molecu...

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Veröffentlicht in:	Molecular neurodegeneration 2015-02, Vol.10 (1), p.5-5, Article 5
Hauptverfasser:	Rosenberger, Karen, Dembny, Paul, Derkow, Katja, Engel, Odilo, Krüger, Christina, Wolf, Susanne A, Kettenmann, Helmut, Schott, Eckart, Meisel, Andreas, Lehnardt, Seija
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Brain Care and treatment Cell Death Cells, Cultured Central Nervous System - metabolism Chaperonin 60 - metabolism Chaperonin 60 - pharmacology Demyelinating Diseases - metabolism Health aspects Heat shock proteins Hostages Injuries Mice, Inbred C57BL Microglia - metabolism Mitogens Myeloid Differentiation Factor 88 - metabolism Nervous system diseases Neurodegenerative Diseases - metabolism Neurons Neurons - metabolism Oligodendroglia - metabolism Receptors, Immunologic - metabolism Signal Transduction - physiology Toll-Like Receptor 4 - metabolism
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