miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency

Enhanced glycolysis is a main feature of pluripotent stem cells (PSCs) and is proposed to be important for the maintenance and induction of pluripotency. The molecular mechanism underlying enhanced glycolysis in PSCs is not clear. Using Dgcr8 −/− mouse embryonic stem cells (ESCs) that lack mature mi...

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Veröffentlicht in:	The EMBO journal 2015-03, Vol.34 (5), p.609-623
Hauptverfasser:	Cao, Yang, Guo, Wen-Ting, Tian, Shengya, He, Xiaoping, Wang, Xi-Wen, Liu, Xiaomeng, Gu, Kai-Li, Ma, Xiaoyu, Huang, De, Hu, Lan, Cai, Yongping, Zhang, Huafeng, Wang, Yangming, Gao, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin Immunoprecipitation DNA Primers - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism EMBO21 EMBO36 EMBO39 Enzymes Gene Knockout Techniques glycolysis Glycolysis - genetics Glycolysis - physiology Mbd2 Metabolic Networks and Pathways - genetics Metabolic Networks and Pathways - physiology Metabolism Mice Mice, Knockout microRNA MicroRNAs - genetics MicroRNAs - metabolism pluripotency Pluripotent Stem Cells - enzymology Pluripotent Stem Cells - physiology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - genetics RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Stem cells
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