Local production of the alternative pathway component factor B is sufficient to promote laser-induced choroidal neovascularization

Complement factor B (CFB) is a required component of the alternative pathway (AP) of complement, and CFB polymorphisms are associated with age-related macular degeneration (AMD) risk. Complement factor B is made in the liver, but expression has also been detected in retina and retinal pigment epithe...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2015-01, Vol.56 (3), p.1850-1863
Hauptverfasser:	Schnabolk, Gloriane, Coughlin, Beth, Joseph, Kusumam, Kunchithapautham, Kannan, Bandyopadhyay, Mausumi, O'Quinn, Elizabeth C, Nowling, Tamara, Rohrer, Bärbel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cells, Cultured Choroid - pathology Choroidal Neovascularization - etiology Choroidal Neovascularization - genetics Choroidal Neovascularization - metabolism Complement Factor B - biosynthesis Complement Factor B - genetics Complement Pathway, Alternative - genetics Disease Models, Animal Electroretinography Enzyme-Linked Immunosorbent Assay Gene Expression Regulation Lasers - adverse effects Mice Mice, Inbred C57BL Mice, Transgenic Real-Time Polymerase Chain Reaction Retinal Pigment Epithelium - pathology Retinal Pigment Epithelium - physiopathology RNA, Messenger - genetics Tomography, Optical Coherence
Online-Zugang:	Volltext
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