Topical Anti-Inflammatory Effects of Isorhamnetin Glycosides Isolated from Opuntia ficus-indica
Opuntia ficus-indica (OFI) has been widely used in Mexico as a food and for the treatment of different health disorders such as inflammation and skin aging. Its biological properties have been attributed to different phytochemicals such as the isorhamnetin glycosides which are the most abundant flav...
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| creator | Serna-Saldívar, Sergio O. Martínez-Vitela, Carlos Gutiérrez-Uribe, Janet A. Antunes-Ricardo, Marilena |
| description | Opuntia ficus-indica (OFI) has been widely used in Mexico as a food and for the treatment of different health disorders such as inflammation and skin aging. Its biological properties have been attributed to different phytochemicals such as the isorhamnetin glycosides which are the most abundant flavonoids. Moreover, these compounds are considered a chemotaxonomic characteristic of OFI species. The aim of this study was to evaluate the effect of OFI extract and its isorhamnetin glycosides on different inflammatory markers in vitro and in vivo. OFI extract was obtained by alkaline hydrolysis of OFI cladodes powder and pure compounds were obtained by preparative chromatography. Nitric oxide (NO), cyclooxygenase-2 (COX-2), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 production were measured. NO production was tested in lipopolysaccharide-stimulated RAW 264.7 cells while in vivo studies were carried on croton oil-induced ear edema model. OFI extract and diglycoside isorhamnetin-glucosyl-rhamnoside (IGR) at 125 ng/mL suppressed the NO production in vitro ( 73.5 ± 4.8 % and 68.7 ± 5.0 %, resp.) without affecting cell viability. Likewise, IGR inhibited the ear edema ( 77.4 ± 5.7 %) equating the indomethacin effects ( 69.5 ± 5.3 %). Both IGR and OFI extract significantly inhibited the COX-2, TNF-α, and IL-6 production. IGR seems to be a suitable natural compound for development of new anti-inflammatory ingredient. |
| doi_str_mv | 10.1155/2015/847320 |
| format | Article |
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Its biological properties have been attributed to different phytochemicals such as the isorhamnetin glycosides which are the most abundant flavonoids. Moreover, these compounds are considered a chemotaxonomic characteristic of OFI species. The aim of this study was to evaluate the effect of OFI extract and its isorhamnetin glycosides on different inflammatory markers in vitro and in vivo. OFI extract was obtained by alkaline hydrolysis of OFI cladodes powder and pure compounds were obtained by preparative chromatography. Nitric oxide (NO), cyclooxygenase-2 (COX-2), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 production were measured. NO production was tested in lipopolysaccharide-stimulated RAW 264.7 cells while in vivo studies were carried on croton oil-induced ear edema model. OFI extract and diglycoside isorhamnetin-glucosyl-rhamnoside (IGR) at 125 ng/mL suppressed the NO production in vitro ( 73.5 ± 4.8 % and 68.7 ± 5.0 %, resp.) without affecting cell viability. Likewise, IGR inhibited the ear edema ( 77.4 ± 5.7 %) equating the indomethacin effects ( 69.5 ± 5.3 %). Both IGR and OFI extract significantly inhibited the COX-2, TNF-α, and IL-6 production. IGR seems to be a suitable natural compound for development of new anti-inflammatory ingredient.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/847320</identifier><identifier>PMID: 25821823</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - chemistry ; Biological activity ; Chromatography ; Croton ; Cytokines ; Cytokines - immunology ; Dose-Response Relationship, Drug ; Glycosides ; Glycosides - administration & dosage ; Glycosides - chemistry ; Health aspects ; Male ; Opuntia - chemistry ; Opuntia ficus-indica ; Otitis Externa - drug therapy ; Otitis Externa - immunology ; Permeability ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Prickly pears ; Quercetin - administration & dosage ; Quercetin - analogs & derivatives ; Quercetin - chemistry ; Rats ; Rats, Wistar ; Treatment Outcome</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-9</ispartof><rights>Copyright © 2015 Marilena Antunes-Ricardo et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Marilena Antunes-Ricardo et al. Marilena Antunes-Ricardo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Marilena Antunes-Ricardo et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-ee1c853098f9c64f70981c6f13cbebc2e3478dc965abecec16bb668e1eabeb4b3</citedby><cites>FETCH-LOGICAL-c491t-ee1c853098f9c64f70981c6f13cbebc2e3478dc965abecec16bb668e1eabeb4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363586/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363586/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25821823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Darvin, Maxim E.</contributor><creatorcontrib>Serna-Saldívar, Sergio O.</creatorcontrib><creatorcontrib>Martínez-Vitela, Carlos</creatorcontrib><creatorcontrib>Gutiérrez-Uribe, Janet A.</creatorcontrib><creatorcontrib>Antunes-Ricardo, Marilena</creatorcontrib><title>Topical Anti-Inflammatory Effects of Isorhamnetin Glycosides Isolated from Opuntia ficus-indica</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Opuntia ficus-indica (OFI) has been widely used in Mexico as a food and for the treatment of different health disorders such as inflammation and skin aging. Its biological properties have been attributed to different phytochemicals such as the isorhamnetin glycosides which are the most abundant flavonoids. Moreover, these compounds are considered a chemotaxonomic characteristic of OFI species. The aim of this study was to evaluate the effect of OFI extract and its isorhamnetin glycosides on different inflammatory markers in vitro and in vivo. OFI extract was obtained by alkaline hydrolysis of OFI cladodes powder and pure compounds were obtained by preparative chromatography. Nitric oxide (NO), cyclooxygenase-2 (COX-2), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 production were measured. NO production was tested in lipopolysaccharide-stimulated RAW 264.7 cells while in vivo studies were carried on croton oil-induced ear edema model. OFI extract and diglycoside isorhamnetin-glucosyl-rhamnoside (IGR) at 125 ng/mL suppressed the NO production in vitro ( 73.5 ± 4.8 % and 68.7 ± 5.0 %, resp.) without affecting cell viability. Likewise, IGR inhibited the ear edema ( 77.4 ± 5.7 %) equating the indomethacin effects ( 69.5 ± 5.3 %). Both IGR and OFI extract significantly inhibited the COX-2, TNF-α, and IL-6 production. IGR seems to be a suitable natural compound for development of new anti-inflammatory ingredient.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Biological activity</subject><subject>Chromatography</subject><subject>Croton</subject><subject>Cytokines</subject><subject>Cytokines - immunology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Glycosides</subject><subject>Glycosides - administration & dosage</subject><subject>Glycosides - chemistry</subject><subject>Health aspects</subject><subject>Male</subject><subject>Opuntia - chemistry</subject><subject>Opuntia ficus-indica</subject><subject>Otitis Externa - drug therapy</subject><subject>Otitis Externa - immunology</subject><subject>Permeability</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Prickly pears</subject><subject>Quercetin - 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Its biological properties have been attributed to different phytochemicals such as the isorhamnetin glycosides which are the most abundant flavonoids. Moreover, these compounds are considered a chemotaxonomic characteristic of OFI species. The aim of this study was to evaluate the effect of OFI extract and its isorhamnetin glycosides on different inflammatory markers in vitro and in vivo. OFI extract was obtained by alkaline hydrolysis of OFI cladodes powder and pure compounds were obtained by preparative chromatography. Nitric oxide (NO), cyclooxygenase-2 (COX-2), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 production were measured. NO production was tested in lipopolysaccharide-stimulated RAW 264.7 cells while in vivo studies were carried on croton oil-induced ear edema model. OFI extract and diglycoside isorhamnetin-glucosyl-rhamnoside (IGR) at 125 ng/mL suppressed the NO production in vitro ( 73.5 ± 4.8 % and 68.7 ± 5.0 %, resp.) without affecting cell viability. Likewise, IGR inhibited the ear edema ( 77.4 ± 5.7 %) equating the indomethacin effects ( 69.5 ± 5.3 %). Both IGR and OFI extract significantly inhibited the COX-2, TNF-α, and IL-6 production. IGR seems to be a suitable natural compound for development of new anti-inflammatory ingredient.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25821823</pmid><doi>10.1155/2015/847320</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | PubMed (Medline); Wiley-Blackwell Open Access Collection; MEDLINE; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Biological activity Chromatography Croton Cytokines Cytokines - immunology Dose-Response Relationship, Drug Glycosides Glycosides - administration & dosage Glycosides - chemistry Health aspects Male Opuntia - chemistry Opuntia ficus-indica Otitis Externa - drug therapy Otitis Externa - immunology Permeability Plant Extracts - administration & dosage Plant Extracts - chemistry Prickly pears Quercetin - administration & dosage Quercetin - analogs & derivatives Quercetin - chemistry Rats Rats, Wistar Treatment Outcome |
| title | Topical Anti-Inflammatory Effects of Isorhamnetin Glycosides Isolated from Opuntia ficus-indica |
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