IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria

Gamma interferon (IFN-γ) drives antiparasite responses and immunopathology during infection with Plasmodium species. Immunity-related GTPases (IRGs) are a class of IFN-γ-dependent proteins that are essential for cell autonomous immunity to numerous intracellular pathogens. However, it is currently u...

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Veröffentlicht in:	Infection and immunity 2015-04, Vol.83 (4), p.1406-1417
Hauptverfasser:	Guo, Jintao, McQuillan, James A, Yau, Belinda, Tullo, Gregory S, Long, Carole A, Bertolino, Patrick, Roediger, Ben, Weninger, Wolfgang, Taylor, Gregory A, Hunt, Nicholas H, Ball, Helen J, Mitchell, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antigens, Protozoan - immunology Brain - immunology Brain - parasitology Brain - pathology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Cell Differentiation - immunology Cell Proliferation - genetics Chemokine CCL2 - biosynthesis Chemokine CCL3 - biosynthesis Chemokine CCL4 - biosynthesis Fungal and Parasitic Infections GTP Phosphohydrolases - genetics GTP Phosphohydrolases - immunology GTP-Binding Proteins - genetics GTP-Binding Proteins - immunology Inflammation - genetics Inflammation - immunology Interferon Type I - biosynthesis Interferon-gamma - immunology Interleukin-6 - biosynthesis Malaria, Cerebral - immunology Malaria, Cerebral - parasitology Mice Mice, Inbred C57BL Mice, Knockout Plasmodium berghei Plasmodium berghei - immunology RNA, Messenger - genetics
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