Dendritic cell-based immunization ameliorates pulmonary infection with highly virulent Cryptococcus gattii

Cryptococcosis due to a highly virulent fungus, Cryptococcus gattii, emerged as an infectious disease on Vancouver Island in Canada and surrounding areas in 1999, causing deaths among immunocompetent individuals. Previous studies indicated that C. gattii strain R265 isolated from the Canadian outbre...

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Veröffentlicht in:	Infection and immunity 2015-04, Vol.83 (4), p.1577-1586
Hauptverfasser:	Ueno, Keigo, Kinjo, Yuki, Okubo, Yoichiro, Aki, Kyoko, Urai, Makoto, Kaneko, Yukihiro, Shimizu, Kiminori, Wang, Dan-Ni, Okawara, Akiko, Nara, Takuya, Ohkouchi, Kayo, Mizuguchi, Yuki, Kawamoto, Susumu, Kamei, Katsuhiko, Ohno, Hideaki, Niki, Yoshihito, Shibuya, Kazutoshi, Miyazaki, Yoshitsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - immunology Cell- and Tissue-Based Therapy Cryptococcosis - immunology Cryptococcosis - prevention & control Cryptococcus Cryptococcus gattii - immunology Dendritic Cells - immunology Dendritic Cells - transplantation Fungal and Parasitic Infections Fungal Capsules - genetics Fungal Capsules - immunology Fungal Vaccines - immunology Giant Cells - immunology Interferon-gamma - genetics Interferon-gamma - immunology Interleukin-17 - immunology Lung - immunology Lung - microbiology Lymphocytes - immunology Mice Mice, Inbred C57BL Mice, Knockout Tumor Necrosis Factor-alpha - immunology Vaccination
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