Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms

Excess weight gain, especially when associated with increased visceral adiposity, is a major cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) hypertension. Increased renal tubular sodium reabsorption impairs pressure natriuresis and plays an important role i...

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Veröffentlicht in:	Circulation research 2015-03, Vol.116 (6), p.991-1006
Hauptverfasser:	Hall, John E, do Carmo, Jussara M, da Silva, Alexandre A, Wang, Zhen, Hall, Michael E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - physiology Animals Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Dyslipidemias - complications Dyslipidemias - physiopathology Heart Conduction System - physiopathology Hemodynamics Humans Hypertension - epidemiology Hypertension - etiology Hypertension - physiopathology Insulin Resistance - physiology Intra-Abdominal Fat - physiopathology Kidney - physiopathology Leptin - physiology Metabolic Syndrome - complications Metabolic Syndrome - physiopathology Models, Animal Models, Cardiovascular Natriuresis - physiology Obesity - complications Obesity - epidemiology Obesity - physiopathology Organ Specificity Parasympathetic Nervous System - physiopathology Pressure Prevalence Pro-Opiomelanocortin - physiology Receptors, Leptin - physiology Renal Insufficiency, Chronic - physiopathology Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology Sodium - metabolism Sympathetic Nervous System - physiopathology
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