Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin

Compelling evidence supports the important role of the glutamatergic system in the pathophysiology of major depression and also as a target for rapid-acting antidepressants. However, the functional role of glutamate release/transmission in behavioral processes related to depression and antidepressan...

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Veröffentlicht in:	Molecular psychiatry 2015-04, Vol.20 (4), p.509-519
Hauptverfasser:	Wang, X, Zhang, D, Lu, X-Y
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/340 692/699/476 AKT protein Animal memory Animals Antidepressants Antidepressive Agents - therapeutic use Aspartic acid Behavior Behavioral despair Behavioral Sciences Biological Psychology CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - pathology Dentate gyrus Dentate Gyrus - drug effects Dentate Gyrus - pathology Depression - drug therapy Depression - pathology Development and progression Disease Models, Animal Dizocilpine Enzyme Inhibitors - pharmacology Excitatory Amino Acid Agents - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Glutamate Glutamatergic transmission Glutamic Acid - metabolism Glutamic acid receptors (ionotropic) Granule cells Health aspects Hippocampus Leptin - therapeutic use Leptin receptors Major depressive disorder Male Medicine Medicine & Public Health Mental depression Methyl aspartate Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity - drug effects N-Methyl-D-aspartic acid receptors N-Methylaspartate - metabolism N-Methylaspartate - pharmacology Neurosciences original-article Pharmacotherapy Psychiatry Psychological aspects Receptors, Leptin - genetics Receptors, Leptin - metabolism RNA, Untranslated - genetics Synapses - drug effects Synaptic Transmission - drug effects Synaptic Transmission - genetics Wakefulness
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