A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging
Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo N , N'...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2015-03, Vol.5 (1), p.9194, Article 9194 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 9194 |
| container_title | Scientific reports |
| container_volume | 5 |
| creator | Eguchi, Haruki Umemura, Masanari Kurotani, Reiko Fukumura, Hidenobu Sato, Itaru Kim, Jeong-Hwan Hoshino, Yujiro Lee, Jin Amemiya, Naoyuki Sato, Motohiko Hirata, Kunio Singh, David J. Masuda, Takatsugu Yamamoto, Masahiro Urano, Tsutomu Yoshida, Keiichiro Tanigaki, Katsumi Yamamoto, Masaki Sato, Mamoru Inoue, Seiichi Aoki, Ichio Ishikawa, Yoshihiro |
| description | Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo
N
,
N'
- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies. |
| doi_str_mv | 10.1038/srep09194 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4361848</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1898633664</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-b47e1253cf200467c21f6e7a549c36e32bcbb9fd8c9c816b536283ebb87099d33</originalsourceid><addsrcrecordid>eNplkU1LAzEQhoMottQe_AOy4ElhNd-bXAQpfkHBix48hc3HrlvapGZ3C_33prTWinPJkHnmnZcZAM4RvEGQiNs2uiWUSNIjMMSQshwTjI8P8gEYt-0MpmBYUiRPwQCzopCEFUPwcZ8tytq7rjFZ6bsmN6U3LmYmLJah9zarQtwRed031tnMunmzcnGdePvbHF0b_KY3a9Jf4-szcFKV89aNd-8IvD8-vE2e8-nr08vkfpobhliXa1o4hBkxFYaQ8sJgVHFXlIxKQ7gjWButZWWFkUYgrhnhWBCntSiglJaQEbjb6i57vXDWON_Fcq6WMfmIaxXKRv2t-OZT1WGlKOFIUJEELncCMXz1ru3ULPTRJ88KCSk4IZzTRF1tKRNDm3Ze7ScgqDaHUPtDJPbi0NKe_Fl7Aq63QJtKvnbxYOQ_tW99hJNT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1898633664</pqid></control><display><type>article</type><title>A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging</title><source>MEDLINE</source><source>PMC (PubMed Central)</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Eguchi, Haruki ; Umemura, Masanari ; Kurotani, Reiko ; Fukumura, Hidenobu ; Sato, Itaru ; Kim, Jeong-Hwan ; Hoshino, Yujiro ; Lee, Jin ; Amemiya, Naoyuki ; Sato, Motohiko ; Hirata, Kunio ; Singh, David J. ; Masuda, Takatsugu ; Yamamoto, Masahiro ; Urano, Tsutomu ; Yoshida, Keiichiro ; Tanigaki, Katsumi ; Yamamoto, Masaki ; Sato, Mamoru ; Inoue, Seiichi ; Aoki, Ichio ; Ishikawa, Yoshihiro</creator><creatorcontrib>Eguchi, Haruki ; Umemura, Masanari ; Kurotani, Reiko ; Fukumura, Hidenobu ; Sato, Itaru ; Kim, Jeong-Hwan ; Hoshino, Yujiro ; Lee, Jin ; Amemiya, Naoyuki ; Sato, Motohiko ; Hirata, Kunio ; Singh, David J. ; Masuda, Takatsugu ; Yamamoto, Masahiro ; Urano, Tsutomu ; Yoshida, Keiichiro ; Tanigaki, Katsumi ; Yamamoto, Masaki ; Sato, Mamoru ; Inoue, Seiichi ; Aoki, Ichio ; Ishikawa, Yoshihiro</creatorcontrib><description>Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo
N
,
N'
- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep09194</identifier><identifier>PMID: 25779357</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/2 ; 13/31 ; 14/28 ; 59/57 ; 631/154/152 ; 631/67/1059/153 ; 639/301/357/354 ; 64/60 ; Animal models ; Animals ; Antineoplastic Agents - administration & dosage ; Apoptosis ; Cancer ; Cell Line, Tumor ; Chemotherapy ; Disease Models, Animal ; Drug delivery ; Drug Delivery Systems ; Ethylenediamines - chemistry ; Humanities and Social Sciences ; Iron ; Iron - chemistry ; Leg ; Magnetic properties ; Magnetic Resonance Imaging ; Magnetite Nanoparticles - chemistry ; Melanoma ; Mice ; Micelles ; Molecular Structure ; multidisciplinary ; Neoplasms - diagnosis ; Neoplasms - drug therapy ; Neoplasms - pathology ; NMR ; Nuclear magnetic resonance ; Precision medicine ; Reactive oxygen species ; Science ; Tumor cell lines</subject><ispartof>Scientific reports, 2015-03, Vol.5 (1), p.9194, Article 9194</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Mar 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited. All rights reserved 2015 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-b47e1253cf200467c21f6e7a549c36e32bcbb9fd8c9c816b536283ebb87099d33</citedby><cites>FETCH-LOGICAL-c515t-b47e1253cf200467c21f6e7a549c36e32bcbb9fd8c9c816b536283ebb87099d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361848/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361848/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25779357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eguchi, Haruki</creatorcontrib><creatorcontrib>Umemura, Masanari</creatorcontrib><creatorcontrib>Kurotani, Reiko</creatorcontrib><creatorcontrib>Fukumura, Hidenobu</creatorcontrib><creatorcontrib>Sato, Itaru</creatorcontrib><creatorcontrib>Kim, Jeong-Hwan</creatorcontrib><creatorcontrib>Hoshino, Yujiro</creatorcontrib><creatorcontrib>Lee, Jin</creatorcontrib><creatorcontrib>Amemiya, Naoyuki</creatorcontrib><creatorcontrib>Sato, Motohiko</creatorcontrib><creatorcontrib>Hirata, Kunio</creatorcontrib><creatorcontrib>Singh, David J.</creatorcontrib><creatorcontrib>Masuda, Takatsugu</creatorcontrib><creatorcontrib>Yamamoto, Masahiro</creatorcontrib><creatorcontrib>Urano, Tsutomu</creatorcontrib><creatorcontrib>Yoshida, Keiichiro</creatorcontrib><creatorcontrib>Tanigaki, Katsumi</creatorcontrib><creatorcontrib>Yamamoto, Masaki</creatorcontrib><creatorcontrib>Sato, Mamoru</creatorcontrib><creatorcontrib>Inoue, Seiichi</creatorcontrib><creatorcontrib>Aoki, Ichio</creatorcontrib><creatorcontrib>Ishikawa, Yoshihiro</creatorcontrib><title>A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo
N
,
N'
- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies.</description><subject>13</subject><subject>13/2</subject><subject>13/31</subject><subject>14/28</subject><subject>59/57</subject><subject>631/154/152</subject><subject>631/67/1059/153</subject><subject>639/301/357/354</subject><subject>64/60</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Disease Models, Animal</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Ethylenediamines - chemistry</subject><subject>Humanities and Social Sciences</subject><subject>Iron</subject><subject>Iron - chemistry</subject><subject>Leg</subject><subject>Magnetic properties</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Melanoma</subject><subject>Mice</subject><subject>Micelles</subject><subject>Molecular Structure</subject><subject>multidisciplinary</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - pathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Precision medicine</subject><subject>Reactive oxygen species</subject><subject>Science</subject><subject>Tumor cell lines</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkU1LAzEQhoMottQe_AOy4ElhNd-bXAQpfkHBix48hc3HrlvapGZ3C_33prTWinPJkHnmnZcZAM4RvEGQiNs2uiWUSNIjMMSQshwTjI8P8gEYt-0MpmBYUiRPwQCzopCEFUPwcZ8tytq7rjFZ6bsmN6U3LmYmLJah9zarQtwRed031tnMunmzcnGdePvbHF0b_KY3a9Jf4-szcFKV89aNd-8IvD8-vE2e8-nr08vkfpobhliXa1o4hBkxFYaQ8sJgVHFXlIxKQ7gjWButZWWFkUYgrhnhWBCntSiglJaQEbjb6i57vXDWON_Fcq6WMfmIaxXKRv2t-OZT1WGlKOFIUJEELncCMXz1ru3ULPTRJ88KCSk4IZzTRF1tKRNDm3Ze7ScgqDaHUPtDJPbi0NKe_Fl7Aq63QJtKvnbxYOQ_tW99hJNT</recordid><startdate>20150317</startdate><enddate>20150317</enddate><creator>Eguchi, Haruki</creator><creator>Umemura, Masanari</creator><creator>Kurotani, Reiko</creator><creator>Fukumura, Hidenobu</creator><creator>Sato, Itaru</creator><creator>Kim, Jeong-Hwan</creator><creator>Hoshino, Yujiro</creator><creator>Lee, Jin</creator><creator>Amemiya, Naoyuki</creator><creator>Sato, Motohiko</creator><creator>Hirata, Kunio</creator><creator>Singh, David J.</creator><creator>Masuda, Takatsugu</creator><creator>Yamamoto, Masahiro</creator><creator>Urano, Tsutomu</creator><creator>Yoshida, Keiichiro</creator><creator>Tanigaki, Katsumi</creator><creator>Yamamoto, Masaki</creator><creator>Sato, Mamoru</creator><creator>Inoue, Seiichi</creator><creator>Aoki, Ichio</creator><creator>Ishikawa, Yoshihiro</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20150317</creationdate><title>A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging</title><author>Eguchi, Haruki ; Umemura, Masanari ; Kurotani, Reiko ; Fukumura, Hidenobu ; Sato, Itaru ; Kim, Jeong-Hwan ; Hoshino, Yujiro ; Lee, Jin ; Amemiya, Naoyuki ; Sato, Motohiko ; Hirata, Kunio ; Singh, David J. ; Masuda, Takatsugu ; Yamamoto, Masahiro ; Urano, Tsutomu ; Yoshida, Keiichiro ; Tanigaki, Katsumi ; Yamamoto, Masaki ; Sato, Mamoru ; Inoue, Seiichi ; Aoki, Ichio ; Ishikawa, Yoshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-b47e1253cf200467c21f6e7a549c36e32bcbb9fd8c9c816b536283ebb87099d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>13</topic><topic>13/2</topic><topic>13/31</topic><topic>14/28</topic><topic>59/57</topic><topic>631/154/152</topic><topic>631/67/1059/153</topic><topic>639/301/357/354</topic><topic>64/60</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Disease Models, Animal</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Ethylenediamines - chemistry</topic><topic>Humanities and Social Sciences</topic><topic>Iron</topic><topic>Iron - chemistry</topic><topic>Leg</topic><topic>Magnetic properties</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Melanoma</topic><topic>Mice</topic><topic>Micelles</topic><topic>Molecular Structure</topic><topic>multidisciplinary</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - pathology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Precision medicine</topic><topic>Reactive oxygen species</topic><topic>Science</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eguchi, Haruki</creatorcontrib><creatorcontrib>Umemura, Masanari</creatorcontrib><creatorcontrib>Kurotani, Reiko</creatorcontrib><creatorcontrib>Fukumura, Hidenobu</creatorcontrib><creatorcontrib>Sato, Itaru</creatorcontrib><creatorcontrib>Kim, Jeong-Hwan</creatorcontrib><creatorcontrib>Hoshino, Yujiro</creatorcontrib><creatorcontrib>Lee, Jin</creatorcontrib><creatorcontrib>Amemiya, Naoyuki</creatorcontrib><creatorcontrib>Sato, Motohiko</creatorcontrib><creatorcontrib>Hirata, Kunio</creatorcontrib><creatorcontrib>Singh, David J.</creatorcontrib><creatorcontrib>Masuda, Takatsugu</creatorcontrib><creatorcontrib>Yamamoto, Masahiro</creatorcontrib><creatorcontrib>Urano, Tsutomu</creatorcontrib><creatorcontrib>Yoshida, Keiichiro</creatorcontrib><creatorcontrib>Tanigaki, Katsumi</creatorcontrib><creatorcontrib>Yamamoto, Masaki</creatorcontrib><creatorcontrib>Sato, Mamoru</creatorcontrib><creatorcontrib>Inoue, Seiichi</creatorcontrib><creatorcontrib>Aoki, Ichio</creatorcontrib><creatorcontrib>Ishikawa, Yoshihiro</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eguchi, Haruki</au><au>Umemura, Masanari</au><au>Kurotani, Reiko</au><au>Fukumura, Hidenobu</au><au>Sato, Itaru</au><au>Kim, Jeong-Hwan</au><au>Hoshino, Yujiro</au><au>Lee, Jin</au><au>Amemiya, Naoyuki</au><au>Sato, Motohiko</au><au>Hirata, Kunio</au><au>Singh, David J.</au><au>Masuda, Takatsugu</au><au>Yamamoto, Masahiro</au><au>Urano, Tsutomu</au><au>Yoshida, Keiichiro</au><au>Tanigaki, Katsumi</au><au>Yamamoto, Masaki</au><au>Sato, Mamoru</au><au>Inoue, Seiichi</au><au>Aoki, Ichio</au><au>Ishikawa, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-03-17</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>9194</spage><pages>9194-</pages><artnum>9194</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo
N
,
N'
- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25779357</pmid><doi>10.1038/srep09194</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2015-03, Vol.5 (1), p.9194, Article 9194 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4361848 |
| source | MEDLINE; PMC (PubMed Central); DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 13 13/2 13/31 14/28 59/57 631/154/152 631/67/1059/153 639/301/357/354 64/60 Animal models Animals Antineoplastic Agents - administration & dosage Apoptosis Cancer Cell Line, Tumor Chemotherapy Disease Models, Animal Drug delivery Drug Delivery Systems Ethylenediamines - chemistry Humanities and Social Sciences Iron Iron - chemistry Leg Magnetic properties Magnetic Resonance Imaging Magnetite Nanoparticles - chemistry Melanoma Mice Micelles Molecular Structure multidisciplinary Neoplasms - diagnosis Neoplasms - drug therapy Neoplasms - pathology NMR Nuclear magnetic resonance Precision medicine Reactive oxygen species Science Tumor cell lines |
| title | A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T12%3A26%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20magnetic%20anti-cancer%20compound%20for%20magnet-guided%20delivery%20and%20magnetic%20resonance%20imaging&rft.jtitle=Scientific%20reports&rft.au=Eguchi,%20Haruki&rft.date=2015-03-17&rft.volume=5&rft.issue=1&rft.spage=9194&rft.pages=9194-&rft.artnum=9194&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep09194&rft_dat=%3Cproquest_pubme%3E1898633664%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1898633664&rft_id=info:pmid/25779357&rfr_iscdi=true |