TRPV4 as a therapeutic target for joint diseases

Biomechanical factors play a critical role in regulating the physiology as well as the pathology of multiple joint tissues and have been implicated in the pathogenesis of osteoarthritis. Therefore, the mechanisms by which cells sense and respond to mechanical signals may provide novel targets for th...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2015-04, Vol.388 (4), p.437-450
Hauptverfasser:	McNulty, Amy L., Leddy, Holly A., Liedtke, Wolfgang, Guilak, Farshid
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Bone and Bones - metabolism Cartilage - metabolism Humans Joint Diseases - drug therapy Joint Diseases - metabolism Joints - metabolism Neurosciences Pain - metabolism Pharmacology/Toxicology Review TRPV Cation Channels - metabolism
Online-Zugang:	Volltext
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