Improving Drug Sensitivity Prediction Using Different Types of Data

The algorithms and models used to address the two subchallenges that are part of the NCI‐DREAM (Dialogue for Reverse Engineering Assessments and Methods) Drug Sensitivity Prediction Challenge (2012) are presented. In subchallenge 1, a bidirectional search algorithm is introduced and optimized using an ensemble scheme and a nonlinear support vector machine (SVM) is then applied to predict the effects of the drug compounds on breast cancer cell lines. In subchallenge 2, a weighted Euclidean distance method is introduced to predict and rank the drug combinations from the most to the least effective in reducing the viability of a diffuse large B‐cell lymphoma (DLBCL) cell line. CPT Pharmacometrics Syst. Pharmacol. (2015) 4, 98–105; doi:10.1002/psp4.2; published online on 18 February 2015.