Obstructive sleep apnea and type 2 diabetes
Type 2 diabetes and obstructive sleep apnea (OSA) are diseases with high prevalence and major public health impact. There is evidence that regular snoring and OSA are independently associated with alterations in glucose metabolism. Thus, OSA might be a risk factor for the development of type 2 diabe...
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| Veröffentlicht in: | European journal of medical research 2010-11, Vol.15 Suppl 2 (S2), p.152-156, Article 152 |
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| container_title | European journal of medical research |
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| creator | Rasche, Kurt Keller, T Tautz, B Hader, C Hergenc, G Antosiewicz, J Di Giulio, C Pokorski, M |
| description | Type 2 diabetes and obstructive sleep apnea (OSA) are diseases with high prevalence and major public health impact. There is evidence that regular snoring and OSA are independently associated with alterations in glucose metabolism. Thus, OSA might be a risk factor for the development of type 2 diabetes. Possible causes might be intermittent hypoxia and sleep fragmentation, which are typical features of OSA. OSA might also be a reason of ineffective treatment of type 2 diabetes. There is further evidence that the treatment of OSA by continuous positive airway pressure (CPAP) therapy might correct metabolic abnormalities in glucose metabolism. It is assumed that this depends on therapy compliance to CPAP. On the other hand, there are also hints in the literature that type 2 diabetes per se might induce sleep apnea, especially in patients with autonomic neuropathy. Pathophysiological considerations open up new insights into that problem. Based on the current scientific data, clinicians have to be aware of the relations between the two diseases, both from the sleep medical and the diabetological point of view. The paper summarizes the most important issues concerning the different associations of OSA and type 2 diabetes. |
| doi_str_mv | 10.1186/2047-783X-15-S2-152 |
| format | Article |
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There is evidence that regular snoring and OSA are independently associated with alterations in glucose metabolism. Thus, OSA might be a risk factor for the development of type 2 diabetes. Possible causes might be intermittent hypoxia and sleep fragmentation, which are typical features of OSA. OSA might also be a reason of ineffective treatment of type 2 diabetes. There is further evidence that the treatment of OSA by continuous positive airway pressure (CPAP) therapy might correct metabolic abnormalities in glucose metabolism. It is assumed that this depends on therapy compliance to CPAP. On the other hand, there are also hints in the literature that type 2 diabetes per se might induce sleep apnea, especially in patients with autonomic neuropathy. Pathophysiological considerations open up new insights into that problem. Based on the current scientific data, clinicians have to be aware of the relations between the two diseases, both from the sleep medical and the diabetological point of view. The paper summarizes the most important issues concerning the different associations of OSA and type 2 diabetes.</description><identifier>ISSN: 0949-2321</identifier><identifier>ISSN: 2047-783X</identifier><identifier>EISSN: 2047-783X</identifier><identifier>DOI: 10.1186/2047-783X-15-S2-152</identifier><identifier>PMID: 21147644</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Chemoreceptor Cells - physiology ; Continuous Positive Airway Pressure ; Development and progression ; Dextrose ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - etiology ; Diabetes therapy ; Diabetic Neuropathies - complications ; Glucose ; Glucose - metabolism ; Humans ; Physiological aspects ; Review ; Risk Factors ; Sleep apnea syndromes ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - etiology ; Snoring - complications ; Type 2 diabetes</subject><ispartof>European journal of medical research, 2010-11, Vol.15 Suppl 2 (S2), p.152-156, Article 152</ispartof><rights>COPYRIGHT 2010 BioMed Central Ltd.</rights><rights>Copyright © 2010 I. 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There is evidence that regular snoring and OSA are independently associated with alterations in glucose metabolism. Thus, OSA might be a risk factor for the development of type 2 diabetes. Possible causes might be intermittent hypoxia and sleep fragmentation, which are typical features of OSA. OSA might also be a reason of ineffective treatment of type 2 diabetes. There is further evidence that the treatment of OSA by continuous positive airway pressure (CPAP) therapy might correct metabolic abnormalities in glucose metabolism. It is assumed that this depends on therapy compliance to CPAP. On the other hand, there are also hints in the literature that type 2 diabetes per se might induce sleep apnea, especially in patients with autonomic neuropathy. Pathophysiological considerations open up new insights into that problem. Based on the current scientific data, clinicians have to be aware of the relations between the two diseases, both from the sleep medical and the diabetological point of view. The paper summarizes the most important issues concerning the different associations of OSA and type 2 diabetes.</description><subject>Chemoreceptor Cells - physiology</subject><subject>Continuous Positive Airway Pressure</subject><subject>Development and progression</subject><subject>Dextrose</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes therapy</subject><subject>Diabetic Neuropathies - complications</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Physiological aspects</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Sleep apnea syndromes</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - etiology</subject><subject>Snoring - complications</subject><subject>Type 2 diabetes</subject><issn>0949-2321</issn><issn>2047-783X</issn><issn>2047-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkV9r2zAUxUXZWEKXT1AohsH2UJxJV38svQxKWbdBoQ9toW9Ctq8TDcfyLLnQb1-bdKGBSnAvXP3OQdIh5IzRNWNafQcqirzQ_DFnMr-DqcIJWR6mH8iSGmFy4MAWZBXjXzotBaow5hNZAGOiUEIsycVtGdMwVsk_YRZbxD5zfYcuc12dpeceM8hq70pMGD-Tj41rI65e-yl5uP55f_U7v7n99efq8iavJIWU1043UhgDspEAZS0a5FKDU6CpkKqoG1MbZ4QomeEMDTWOK81lBZJKrSg_JT_2vv1Y7rCusEuDa20_-J0bnm1w3h6fdH5rN-HJCq4oaJgMvr0aDOHfiDHZnY8Vtq3rMIzRaqCFUSBn8sue3LgWre-aMBlWM20vhRTAKFN8otbvUNOuceer0GHjp_mR4OsbwRZdm7YxtGPyoYvHIN-D1RBiHLA5vJJROwdt50jtHKll0t7BVOdbn7_9oIPmf6z8BRprn48</recordid><startdate>20101104</startdate><enddate>20101104</enddate><creator>Rasche, Kurt</creator><creator>Keller, T</creator><creator>Tautz, B</creator><creator>Hader, C</creator><creator>Hergenc, G</creator><creator>Antosiewicz, J</creator><creator>Di Giulio, C</creator><creator>Pokorski, M</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101104</creationdate><title>Obstructive sleep apnea and type 2 diabetes</title><author>Rasche, Kurt ; 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There is evidence that regular snoring and OSA are independently associated with alterations in glucose metabolism. Thus, OSA might be a risk factor for the development of type 2 diabetes. Possible causes might be intermittent hypoxia and sleep fragmentation, which are typical features of OSA. OSA might also be a reason of ineffective treatment of type 2 diabetes. There is further evidence that the treatment of OSA by continuous positive airway pressure (CPAP) therapy might correct metabolic abnormalities in glucose metabolism. It is assumed that this depends on therapy compliance to CPAP. On the other hand, there are also hints in the literature that type 2 diabetes per se might induce sleep apnea, especially in patients with autonomic neuropathy. Pathophysiological considerations open up new insights into that problem. 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| source | MEDLINE; SpringerLink_现刊; Springer_OA刊; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Chemoreceptor Cells - physiology Continuous Positive Airway Pressure Development and progression Dextrose Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - etiology Diabetes therapy Diabetic Neuropathies - complications Glucose Glucose - metabolism Humans Physiological aspects Review Risk Factors Sleep apnea syndromes Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - etiology Snoring - complications Type 2 diabetes |
| title | Obstructive sleep apnea and type 2 diabetes |
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